ArticleInternational journal of endocrinology2015
Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer.
Article in International journal of endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- A systematic review of genetic association studies on the susceptibility of preterm birth in Asia.Molecular genetics and genomics : MGG · 2025Pooled it
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- Leptin and Leptin Receptor Polymorphisms in Infants and Their Parents: Correlation with Preterm Birth.Genes · 2024Article
- Serum Leptin Receptor and the rs1137101 Variant of theBiomolecules · 2023Article
- Leptin and the rs2167270 Polymorphism Are Associated with Glycemic Control in Type Two Diabetes Mellitus Patients on Metformin Therapy.Medicina (Kaunas, Lithuania) · 2023Article
- A GWAS top hit for circulating leptin is associated with weight gain but not with leptin protein levels in lithium-augmented patients with major depression.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2021Article
- Article
- Article
- The Inter-Relation between Leptin Receptor (Q223R) Gene Polymorphism and the Risk of Egyptian Patients with HCC.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Methylation of the LEP gene promoter in blood at 12 months and BMI at 4 years of age-a population-based cohort study.International journal of obesity (2005) · 2020Article
- Investigation ofAmerican journal of translational research · 2020Article
- Genetic variation, intrauterine growth, and adverse pregnancy conditions predict leptin gene DNA methylation in blood at birth and 12 months of age.International journal of obesity (2005) · 2020Article
- Article
- Association between leptin gene rs7799039 polymorphism and lipid profile changes induced by isotretinoin treatment in acne patients.Therapeutics and clinical risk management · 2018Article
- Investigation ofOncoTargets and therapy · 2018Article
- Effects of maternal and fetal LEP common variants on maternal glycemic traits in pregnancy.Scientific reports · 2017Article
- Investigation ofOncotarget · 2017Article
- A new panel of SNPs to assess thyroid carcinoma risk: a pilot study in a Brazilian admixture population.BMC medical genetics · 2017Article
- Maternal pre-pregnancy BMI downregulates neonatal cord blood LEP methylation.Pediatric obesity · 2017Article
- The Relationship Between Gene Polymorphism of Leptin and Leptin Receptor and Growth Hormone Deficiency.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose. To understand the role of polymorphisms in the LEP (rs7799039 and rs2167270) and LEPR (rs1137101 and rs1137100) genes in DTC susceptibility and their effect on leptin levels. Methods. We studied 153 patients with DTC and 234 controls through TaqMan SNP Genotyping and ELISA, comparing these data to the clinicopathological data of patients with DTC. Results. Patients with AA genotype of rs7799039 had higher levels of serum leptin (9.22 ± 0.98 ng/mL) than those with AG genotype (10.07 ± 0.60 ng/mL; P = 0.005). Individuals with AG genotype of rs2167270 also produced higher serum leptin levels (10.05 ± 0.59 ng/mL) than the subjects with GG genotype (9.52 ± 0.79 ng/mL; P < 0.05). A multivariate logistic regression adjusted for gender, age, and BMI showed that the AG genotype of rs7799039 was an independent risk for DTC (OR, 11.689; P = 0.0183; 95% CI, 1.516-90.119). Similarly, AG and GG genotypes of rs1137101 increased the susceptibility to DTC (OR, 3.747; P = 0.027; 95% CI, 1.161-12.092 and OR, 5.437; P = 0.013; 95% CI, 1.426-20.729). Conclusions. We demonstrated that rs7799039 and rs2167270 polymorphisms modify the serum leptin concentrations in patients with DTC. Furthermore, polymorphisms rs7799039 and rs1137101 increase the risk of DTC development, although they do not correlate with tumor aggressiveness.
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