Evidence map›Paper›PMID 25810563›Full record

ArticleDisease markers2015

Polymorphisms rs12998 and rs5780218 in KiSS1 suppressor metastasis gene in Mexican patients with breast cancer.

Edhit Guadalupe Cruz Quevedo, Gabriela Monserrat Mimendi Aguilar, Luis Anselmo Juárez Aguilar, Susan Andrea Gutierrez Rubio, Silvia Esperanza Flores Martínez, Ingrid Patricia Dávalos Rodríguez, José Sánchez Corona, Martha Isabel Torres Morán, Roberto Carlos Rosales Gómez, María Cristina Morán Moguel

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Genetic Variants inGenes · 2024
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  9. Computational study of putative functional variants in human kisspeptin.Journal, genetic engineering & biotechnology · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Edhit Guadalupe Cruz QuevedoDivisión de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada, No. 800, Colonia Independencia, 44340 Guadalajara, JAL, Mexico.
Gabriela Monserrat Mimendi AguilarDivisión de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada, No. 800, Colonia Independencia, 44340 Guadalajara, JAL, Mexico ; Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada, No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico.
Luis Anselmo Juárez AguilarDivisión de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada, No. 800, Colonia Independencia, 44340 Guadalajara, JAL, Mexico ; Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada, No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico.
Susan Andrea Gutierrez RubioLaboratorio de Inmunología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada, No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico.
Silvia Esperanza Flores MartínezDivisión de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada, No. 800, Colonia Independencia, 44340 Guadalajara, JAL, Mexico.
Ingrid Patricia Dávalos RodríguezDivisión de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada, No. 800, Colonia Independencia, 44340 Guadalajara, JAL, Mexico.
José Sánchez CoronaDivisión de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada, No. 800, Colonia Independencia, 44340 Guadalajara, JAL, Mexico.
Martha Isabel Torres MoránIMAREFI, Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara, Camino Ing. Ramón Padilla Sánchez, No. 2100, Nextipac, 44600 Zapopan, JAL, Mexico.
Roberto Carlos Rosales GómezDivisión de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada, No. 800, Colonia Independencia, 44340 Guadalajara, JAL, Mexico.
María Cristina Morán MoguelDivisión de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada, No. 800, Colonia Independencia, 44340 Guadalajara, JAL, Mexico.
Mexican Social Security Institute · MXUniversidad de Guadalajara · MX

Funding

DNA SAMPLE ANALYSIS27307C2007 · NIEHS · PI LEHMAN, TERESA · 2007 to 2007
$74k
NIEHS NIH HHS 27307C2007
6 · The paper itself

Abstract

aimsKiSS1 is a metastasis suppressor gene associated with inhibition of cellular chemotaxis and invasion attenuating the metastasis in melanoma and breast cancer cell lines. Along the KiSS-1 gene at least 294 SNPs have been described; however the association of these polymorphisms as genetic markers for metastasis in breast cancer studies has not been investigated. Here we describe two simple PCR-RFLPs protocols to identify the rs5780218 (9DelT) and the rs12998 (E20K) KiSS1 polymorphisms and the allelic, genotypic, and haplotypic frequencies in Mexican general population (GP) and patients with benign breast disease (BBD) or breast cancer (BC).

resultsThe rs5780218 polymorphism was individually associated with breast cancer (P = 0.0332) and the rs12998 polymorphism shows statistically significant differences when GP versus case (BC and BBD) groups were compared (P < 0.0001). The H1 Haplotype (G/-) occurred more frequently in BC group (0.4256) whereas H2 haplotype (G/T) was the most prevalent in BBD group (0.4674).

conclusionsOur data indicated that the rs5780218 polymorphism individually confers susceptibility for development of breast cancer in Mexican population and a possible role as a genetic marker in breast cancer metastasis for H1 haplotype (Wt/variant) in KiSS1 gene must be analyzed in other populations.

Indexed as

Polymorphism, Single NucleotideAdultAgedBreast NeoplasmsCarcinomaCase-Control StudiesFemaleHumansKisspeptinsMexicoMiddle AgedKISS1 protein, humanKisspeptins

Identifiers

PMID25810563
PMCPMC4355114
OpenAlexW1996951844

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.