Evidence map›Paper›PMID 25810543›Full record

ArticleJournal of virology2015

Structure of Serotype 1 Reovirus Attachment Protein σ1 in Complex with Junctional Adhesion Molecule A Reveals a Conserved Serotype-Independent Binding Epitope.

Eva Stettner, Melanie H Dietrich, Kerstin Reiss, Terence S Dermody, Thilo Stehle

Abstract read
In one paragraph

Article in Journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. NgR1 binding to reovirus reveals an unusual bivalent interaction and a new viral attachment protein.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  3. Deciphering molecular mechanisms stabilizing the reovirus-binding complex.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eva StettnerInterfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
Melanie H DietrichInterfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
Kerstin ReissInterfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
Terence S DermodyDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, Tennessee, USA Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA thilo.stehle@uni-tuebingen.de terry.dermody@vanderbilt.edu.
Thilo StehleInterfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA thilo.stehle@uni-tuebingen.de terry.dermody@vanderbilt.edu.

Funding

Structural Analysis of Reovirus Attachment MechanismsR01AI076983 · NIAID · VANDERBILT UNIVERSITY · PI DERMODY, TERENCE S., STEHLE, THILO · 2009 to 2013
$1.6M
NIAID NIH HHS R01 AI076983
6 · The paper itself

Abstract

Mammalian orthoreoviruses use glycans and junctional adhesion molecule A (JAM-A) as attachment receptors. We determined the structure of serotype 1 reovirus attachment protein σ1 alone and in complex with JAM-A. Comparison with the structure of serotype 3 reovirus σ1 bound to JAM-A reveals that both σ1 proteins engage JAM-A with similar affinities and via conserved binding epitopes. Thus, σ1-JAM-A interactions are unlikely to explain the differences in pathogenesis displayed by these reovirus serotypes.

Indexed as

Amino Acid SequenceBinding SitesCapsid ProteinsCrystallography, X-RayJunctional Adhesion Molecule AModels, MolecularMolecular Sequence DataProtein BindingProtein ConformationReceptors, VirusSequence HomologyCapsid ProteinsJunctional Adhesion Molecule AReceptors, Virussigma 1 protein, reovirus

Identifiers

PMID25810543
PMCPMC4442426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.