ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Blockade of glutamatergic transmission in perirhinal cortex impairs object recognition memory in macaques.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Focal pharmacological manipulation of serotonin signaling in the amygdala does not alter social behavior.Psychopharmacology · 2025Article
- Pharmacological Inactivation of the Bed Nucleus of the Stria Terminalis Increases Affiliative Social Behavior in Rhesus Macaques.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Endocytosis is required for consolidation of pattern-separated memories in the perirhinal cortex.Frontiers in systems neuroscience · 2023Article
- The Parahippocampal Cortex and its Functional Connection with the Hippocampus are Critical for Nonnavigational Spatial Memory in Macaques.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- AMPA receptors mediate the pro-cognitive effects of electrical and optogenetic stimulation of the medial prefrontal cortex in antidepressant non-responsive Wistar-Kyoto rats.Journal of psychopharmacology (Oxford, England) · 2020Article
- Dysregulation of behavioral and autonomic responses to emotional and social stimuli following bidirectional pharmacological manipulation of the basolateral amygdala in macaques.Neuropharmacology · 2020Article
- Frontal and Insular Input to the Dorsolateral Temporal Pole in Primates: Implications for Auditory Memory.Frontiers in neuroscience · 2019Article
- Chemogenetic activation of the perirhinal cortex reverses methamphetamine-induced memory deficits and reduces relapse.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Mediodorsal thalamus is required for discrete phases of goal-directed behavior in macaques.eLife · 2018Article
- Angiotensin II Type 1 Receptor Blockers Inhibit KAT II Activity in the Brain-Its Possible Clinical Applications.Neurotoxicity research · 2017Article
- Blockade of glutamatergic transmission in the primate basolateral amygdala suppresses active behavior without altering social interaction.Behavioral neuroscience · 2017Article
- Defensive Vocalizations and Motor Asymmetry Triggered by Disinhibition of the Periaqueductal Gray in Non-human Primates.Frontiers in neuroscience · 2017Article
- Bidirectional Control of Social Behavior by Activity within Basolateral and Central Amygdala of Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Perirhinal Cortex mGlu5 Receptor Activation Reduces Relapse to Methamphetamine Seeking by Restoring Novelty Salience.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Failure to Recognize Novelty after Extended Methamphetamine Self-Administration Results from Loss of Long-Term Depression in the Perirhinal Cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- The piriform, perirhinal, and entorhinal cortex in seizure generation.Frontiers in neural circuits · 2015Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The perirhinal cortex (PRc) is essential for visual recognition memory, as shown by electrophysiological recordings and lesion studies in a variety of species. However, relatively little is known about the functional contributions of perirhinal subregions. Here we used a systematic mapping approach to identify the critical subregions of PRc through transient, focal blockade of glutamate receptors by intracerebral infusion of kynurenic acid. Nine macaques were tested for visual recognition memory using the delayed nonmatch-to-sample task. We found that inactivation of medial PRc (consisting of Area 35 together with the medial portion of Area 36), but not lateral PRc (the lateral portion of Area 36), resulted in a significant delay-dependent impairment. Significant impairment was observed with 30 and 60 s delays but not with 10 s delays. The magnitude of impairment fell within the range previously reported after PRc lesions. Furthermore, we identified a restricted area located within the most anterior part of medial PRc as critical for this effect. Moreover, we found that focal blockade of either NMDA receptors by the receptor-specific antagonist AP-7 or AMPA receptors by the receptor-specific antagonist NBQX was sufficient to disrupt object recognition memory. The present study expands the knowledge of the role of PRc in recognition memory by identifying a subregion within this area that is critical for this function. Our results also indicate that, like in the rodent, both NMDA and AMPA-mediated transmission contributes to object recognition memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.