ArticleThe Journal of infectious diseases2015
Analysis of Breath Specimens for Biomarkers of Plasmodium falciparum Infection.
Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Volatile Organic Compounds in Human Exhaled Breath to Diagnose Gastrointestinal Cancer: A Meta-Analysis.Frontiers in oncology · 2021Pooled it
- Comparing patterns of volatile organic compounds exhaled in breath after consumption of two infant formulae with a different lipid structure: a randomized trial.Scientific reports · 2019Trial
- Diurnal variation in expired breath volatiles in malaria-infected and healthy volunteers.Journal of breath research · 2018Trial
- Trial
- Noninvasive malaria detection beyond blood sampling.Sensors & diagnostics · 2026Review
- Breath Biomarkers of Pediatric Malaria: Reproducibility and Response to Antimalarial Therapy.The Journal of infectious diseases · 2024Article
- Combination of real-time and hyphenated mass spectrometry for improved characterisation of exhaled breath biomarkers in clinical research.Analytical and bioanalytical chemistry · 2024Article
- The State of the Art on Graphene-Based Sensors for Human Health Monitoring through Breath Biomarkers.Sensors (Basel, Switzerland) · 2023Review
- Volatile profiling distinguishesmSphere · 2023Article
- Manipulation by Plasmodium Parasites of Anopheles Mosquito Behavior and Human Odors.Acta parasitologica · 2022Review
- Breath Metabolites to Diagnose Infection.Clinical chemistry · 2021Review
- The Potential Use of Volatile Biomarkers for Malaria Diagnosis.Diagnostics (Basel, Switzerland) · 2021Review
- A unique volatile signature distinguishes malaria infection from other conditions that cause similar symptoms.Scientific reports · 2021Article
- Breath-Based Diagnosis of Infectious Diseases: A Review of the Current Landscape.Clinics in laboratory medicine · 2021Review
- Reproducible breath metabolite changes in children with SARS-CoV-2 infection.medRxiv : the preprint server for health sciences · 2021Article
- Challenges in forming inferences from limited data: a case study of malaria parasite maturation.Journal of the Royal Society, Interface · 2021Article
- An Update on the Use of Exhaled Breath Analysis for the Early Detection of Lung Cancer.Lung Cancer (Auckland, N.Z.) · 2021Review
- Variability in human attractiveness to mosquitoes.Current research in parasitology & vector-borne diseases · 2021Review
- Olfaction in Anopheles mosquitoes.Chemical senses · 2021Review
- Volatile Cues Influence Host-Choice in Arthropod Pests.Animals : an open access journal from MDPI · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Currently, the majority of diagnoses of malaria rely on a combination of the patient's clinical presentation and the visualization of parasites on a stained blood film. Breath offers an attractive alternative to blood as the basis for simple, noninvasive diagnosis of infectious diseases. In this study, breath samples were collected from individuals during controlled malaria to determine whether specific malaria-associated volatiles could be detected in breath. We identified 9 compounds whose concentrations varied significantly over the course of malaria: carbon dioxide, isoprene, acetone, benzene, cyclohexanone, and 4 thioethers. The latter group, consisting of allyl methyl sulfide, 1-methylthio-propane, (Z)-1-methylthio-1-propene, and (E)-1-methylthio-1-propene, had not previously been associated with any disease or condition. Before the availability of antimalarial drug treatment, there was evidence of concurrent 48-hour cyclical changes in the levels of both thioethers and parasitemia. When thioether concentrations were subjected to a phase shift of 24 hours, a direct correlation between the parasitemia and volatile levels was revealed. Volatile levels declined monotonically approximately 6.5 hours after initial drug treatment, correlating with clearance of parasitemia. No thioethers were detected in in vitro cultures of Plasmodium falciparum. The metabolic origin of the thioethers is not known, but results suggest that interplay between host and parasite metabolic pathways is involved in the production of these thioethers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.