ReviewASN neuro
Hypocalcemia-induced seizure: demystifying the calcium paradox.
Review in ASN neuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Pooled it
- Diagnosis and treatment of hypoparathyroidism: a position statement from the Brazilian Society of Endocrinology and Metabolism.Archives of endocrinology and metabolism · 2018Guideline
- Divalent cation depletion enhances intrinsic neuronal excitability through CaSR-dependent modulation of threshold ion channels.PNAS nexus · 2026Article
- Severe Vitamin D Deficiency as a Trigger for Metabolic Seizures in Infancy: A Case Series and a Comprehensive Review of the Literature.Nutrients · 2026Review
- Refractory seizures as a manifestation of anti-epileptic drug induced hypocalcemia and vitamin D deficiency.JCEM case reports · 2026Article
- Troubleshooting Ionized Hypocalcemia in Patients on Continuous KRT with Regional Citrate Anticoagulation.Kidney360 · 2026Review
- A predictive model for central nervous system infections in children based on machine learning and clinical diagnostic features.Frontiers in pediatrics · 2026Article
- Severity, etiology and outcomes of ionized hypocalcemia in azotemic cats and dogs.Frontiers in veterinary science · 2026Article
- Complex Febrile Seizures As the Initial Presentation of Nutritional Rickets Due to Severe Vitamin D Deficiency.Cureus · 2025Article
- Case Report: Personalizing Transcranial Magnetic Stimulation Therapy for Treatment-Resistant Depression for a Patient with Complex Medical History.Harvard review of psychiatry · 2025Article
- Article
- Diagnostic Challenges in Fahr's Disease: A Rare Case of Extensive Basal Ganglia Calcifications.Cureus · 2025Article
- Unraveling the nutritional challenges in epilepsy: Risks, deficiencies, and management strategies: A systematic review.World journal of experimental medicine · 2025Article
- Cadherin-16 regulates acoustic sensory gating in zebrafish through endocrine signaling.PLoS biology · 2025Article
- A Rare Presentation of Hypocalcaemia-Induced Seizure Secondary to Late-Onset Post-Thyroidectomy Complication.Cureus · 2025Article
- Novel TRPM3 missense mutation leading to severe hypocalcemia presenting as seizures and complicated by non-sustained ventricular tachycardia: A case report.Qatar medical journal · 2025Article
- Influential factors related to feeding disorders in preterm infants and the construction of predictive models.Frontiers in pediatrics · 2025Article
- Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of CaMolecular therapy. Nucleic acids · 2024Article
- Pseudohypoparathyroidism leading to bilateral hip fracture: A case report.Radiology case reports · 2024Article
- Neurosteroids Alter p-ERK Levels and Tau Distribution, Restraining the Effects of High Extracellular Calcium.International journal of molecular sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium is essential for both neurotransmitter release and muscle contraction. Given these important physiological processes, it seems reasonable to assume that hypocalcemia may lead to reduced neuromuscular excitability. Counterintuitively, however, clinical observation has frequently documented hypocalcemia's role in induction of seizures and general excitability processes such as tetany, Chvostek's sign, and bronchospasm. The mechanism of this calcium paradox remains elusive, and very few pathophysiological studies have addressed this conundrum. Nevertheless, several studies primarily addressing other biophysical issues have provided some clues. In this review, we analyze the data of these studies and propose an integrative model to explain this hypocalcemic paradox.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.