Evidence map›Paper›PMID 25810263›Full record

GuidelinePediatric blood & cancer2015

SIOP-PODC adapted risk stratification and treatment guidelines: Recommendations for neuroblastoma in low- and middle-income settings.

Nehal S Parikh, Scott C Howard, Guillermo Chantada, Trijn Israels, Mohammed Khattab, Patricia Alcasabas, Catherine G Lam, Lawrence Faulkner, Julie R Park, Wendy B London and 2 more

Registry-linked trialAbstract readPractice Guideline
In one paragraph

Guideline in Pediatric blood & cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06928909 (Evaluating the Feasibility of an Intensity-Adapted Pediatric Acute Myeloid Leukemia Treatment Guideline in Malawi), which is not on this map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06928909 recruitingnot on this mapstarted 2025, after this paper: background citation

Evaluating the Feasibility of an Intensity-Adapted Pediatric Acute Myeloid Leukemia Treatment Guideline in Malawi

TypeobservationalSponsorBaylor College of MedicineRan2025 to 2030Enrolled30ConditionsAcute Myeloid LeukaemiaArmsIntensity-adapted pediatric acute myeloid treatment guidelines
3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. [JMIR research protocols · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. micro-RNA 451-a as a Circulating Biomarker for Neuroblastoma.MicroRNA (Shariqah, United Arab Emirates) · 2025
    Article
  10. Review
  11. Prognostic factors of neuroblastoma in limited-resource settings.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2025
    Article
  12. Review
  13. Review
  14. Exploring treatment decision-making at diagnosis for children with advanced cancer in low- and middle-income countries.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Laparoscopic approach of pediatric adrenal tumors.Pediatric surgery international · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nehal S ParikhDepartment of Pediatrics, Division of Hematology-Oncology, Connecticut Children's Medical Center, Hartford, Connecticut.
Scott C HowardUniversity of Memphis, Memphis, Tennessee.
Guillermo ChantadaDepartment of Hemato-oncology, Hospital JP Garrahan, Buenos Aires, Argentina.
Trijn IsraelsVU University Medical Center, Amsterdam, the Netherlands.
Mohammed KhattabDepartment of Paediatrics, Children's Hospital of Rabat, Rabat, Morocco.
Patricia AlcasabasUniversity of the Philippines-Philippine General Hospital, Manila, Philippines.
Catherine G LamDepartment of Oncology and International Outreach Program, St. Jude Children's Research Hospital, Memphis, Tennessee.
Lawrence FaulknerCure2Children Foundation, Florence, Italy.
Julie R ParkSeattle Children's Hospital, University of Washington School of Medicine and Fred Hutchinson Cancer Research Center, Seattle, Washington.
Wendy B LondonHarvard Medical School, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, Maryland.
Katherine K MatthayDepartment of Pediatrics, UCSF School of Medicine and UCSF Benioff Children's Hospital, San Francisco, California.
International Society of Pediatric Oncology

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroblastoma is the most common extracranial solid tumor in childhood in high-income countries (HIC), where consistent treatment approaches based on clinical and tumor biological risk stratification have steadily improved outcomes. However, in low- and middle- income countries (LMIC), suboptimal diagnosis, risk stratification, and treatment may occur due to limited resources and unavailable infrastructure. The clinical practice guidelines outlined in this manuscript are based on current published evidence and expert opinions. Standard risk stratification and treatment explicitly adapted to graduated resource settings can improve outcomes for children with neuroblastoma by reducing preventable toxic death and relapse.

Indexed as

Developing CountriesHumansInfantInfant, NewbornNeoplasm Recurrence, LocalNeoplasm StagingNeuroblastomaPovertyRadiographyRadionuclide ImagingRiskSocioeconomic Factorsdiagnosislow income countriesMYCNNeuroblastomaresource limited countriestreatment

Identifiers

PMID25810263
PMCPMC5132052

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.