ArticleJournal of human hypertension2015
Vitamin D status, hypertension and ischemic stroke: a clinical perspective.
Article in Journal of human hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 31 citations in OpenAlex.
- Prevalence and Outcomes Associated with Vitamin D Deficiency among Indexed Hospitalizations with Cardiovascular Disease and Cerebrovascular Disorder-A Nationwide Study.Medicines (Basel, Switzerland) · 2020Article
- Lower levels of vitamin D are associated with SARS-CoV-2 infection and mortality in the Indian population: An observational study.International immunopharmacology · 2020Observational
- Vitamin D serum level in subjects with critical illness polyneuropathy and myopathy.Journal of musculoskeletal & neuronal interactions · 2020Article
- The combined presence of hypertension and vitamin D deficiency increased the probability of the occurrence of small vessel disease in China.BMC neurology · 2019Article
- No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases.Biological reviews of the Cambridge Philosophical Society · 2018Review
- Association of Serum 25(OH) D Levels with Infarct Volumes and Stroke Severity in Acute Ischemic Stroke.The journal of nutrition, health & aging · 2018Article
- Vitamin D deficiency is associated with acute ischemic stroke, C-reactive protein, and short-term outcome.Metabolic brain disease · 2017Article
- Parathyroid Hormone Levels in the Prediction of Ischemic Stroke Risk.Disease markers · 2017Article
- Vitamin D and Cerebrovascular Disease.Annals of Indian Academy of NeurologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between vitamin D deficiency and stroke was cross-sectionally evaluated in the high-risk Asian Indian population. Age- and gender-matched, 239 ischemic stroke patients and 241 control subjects were recruited. Vitamin D status was estimated by measuring serum 25-hydroxyvitamin D (25(OH)D) levels. After multivariate adjustment for a range of potential covariates in a logistic regression model, an inverse association was found between serum 25(OH)D concentration and risk of ischemic stroke: subjects with severely low 25(OH)D levels (⩽9.33 ng ml(-1)) were found to be at 3.13-fold (95% confidence interval (CI), (1.22-8.07)) increased risk of ischemic stroke as compared with those with high levels. Adjustment for systolic blood pressure levels was found to abrogate this association (odds ratio (OR)=2.00, 95% CI=0.61-6.50). On stratification, a pronounced association was found between low 25(OH)D and risk of ischemic stroke in hypertensives, OR=13.54, 95% CI=1.94-94.43 as compared with no association in non-hypertensives, (Pinteraction=0.04). We conclude that high blood pressure partly explains the association between 25(OH)D levels and ischemic stroke. Presence of hypertension amply aggravates the risk of ischemic stroke associated with low vitamin D levels. Meticulous management of hypertension, regular monitoring of serum 25(OH)D levels and treatment of severe vitamin D deficiency, particularly in hypertensive subjects, could help in effective prevention of stroke.
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