Evidence map›Paper›PMID 25810047›Full record

GuidelineThyroid : official journal of the American Thyroid Association2015

Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma.

Samuel A Wells, Sylvia L Asa, Henning Dralle, Rossella Elisei, Douglas B Evans, Robert F Gagel, Nancy Lee, Andreas Machens, Jeffrey F Moley, Furio Pacini and 9 more

2 registry-linked trialsAbstract readPractice GuidelineReview
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Thyroid : official journal of the American Thyroid Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 999 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
999citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06067594 completednot on this mapstarted 2018, after this paper: background citation

Optimizing Diagnostic Accuracy of Fine Needle Aspiration Biopsy Calcitonin Measurements in Detecting Medullary Thyroid Carcinoma

Typeobservational_patient_registrySponsorAustral University, ArgentinaRan2018 to 2022Enrolled155ConditionsMedullary Thyroid Carcinoma, Nodular GoiterArmsFine Needle Aspiration Cytology (FNAC) procedure+calcitonin measurement
NCT06523582 recruitingnot on this mapstarted 2022, after this paper: background citation

Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients

TypeobservationalSponsorUniversidad Nacional Autonoma de MexicoRan2022 to 2037Enrolled750ConditionsNeuroendocrine Neoplasm, Neuroendocrine Neoplasm of Gastrointestinal Tract, Neuroendocrine Neoplasm of Lung, Thymic Neuroendocrine Neoplasm
3 · Its place in the literature

Who cites it

999 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Clinical Outcomes of the GermlineMedicina (Kaunas, Lithuania) · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Guideline
  8. Covalent FAPI Imaging-Guided Precision Surgery in Patients with Medullary Thyroid Carcinoma: A Phase II Clinical Trial.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Trial
  9. Application of theranostics in thyroid cancer management.The Journal of clinical endocrinology and metabolism · 2026
    Review
  10. Article
  11. Clinical performance of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Rare solid tumours as indicators of hereditary cancer syndromes.European journal of human genetics : EJHG · 2026
    Review
  19. Article
  20. Article

939 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Samuel A Wells1Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Sylvia L Asa2Department of Pathology, University Health Network, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Henning Dralle3Department of General, Visceral, and Vascular Surgery, University Hospital, University of Halle-Wittenberg, Halle/Saale, Germany.
Rossella Elisei4Department of Endocrinology, University of Pisa, Pisa, Italy.
Douglas B Evans5Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
Robert F Gagel6Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Nancy Lee7Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York.
Andreas Machens3Department of General, Visceral, and Vascular Surgery, University Hospital, University of Halle-Wittenberg, Halle/Saale, Germany.
Jeffrey F Moley8Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
Furio Pacini9Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Policlinico Santa Maria alle Scotte, Siena, Italy.
Friedhelm Raue10Endocrine Practice, Moleculargenetic Laboratory, Medical Faculty, University of Heidelberg, Heidelberg, Germany.
Karin Frank-Raue10Endocrine Practice, Moleculargenetic Laboratory, Medical Faculty, University of Heidelberg, Heidelberg, Germany.
Bruce Robinson11University of Sydney School of Medicine, Sydney, New South Wales, Australia.
M Sara Rosenthal12Departments of Internal Medicine, Pediatrics and Behavioral Science, University of Kentucky, Lexington, Kentucky.
Massimo Santoro13Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universita' di Napoli "Federico II," Napoli, Italy.
Martin Schlumberger14Institut Gustave Roussy, Service de Medecine Nucleaire, Université of Paris-Sud, Villejuif, France.
Manisha Shah15Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.
Steven G Waguespack6Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
6 · The paper itself

Abstract

introductionThe American Thyroid Association appointed a Task Force of experts to revise the original Medullary Thyroid Carcinoma: Management Guidelines of the American Thyroid Association.

methodsThe Task Force identified relevant articles using a systematic PubMed search, supplemented with additional published materials, and then created evidence-based recommendations, which were set in categories using criteria adapted from the United States Preventive Services Task Force Agency for Healthcare Research and Quality. The original guidelines provided abundant source material and an excellent organizational structure that served as the basis for the current revised document.

resultsThe revised guidelines are focused primarily on the diagnosis and treatment of patients with sporadic medullary thyroid carcinoma (MTC) and hereditary MTC.

conclusionsThe Task Force developed 67 evidence-based recommendations to assist clinicians in the care of patients with MTC. The Task Force considers the recommendations to represent current, rational, and optimal medical practice.

Indexed as

ThyroidectomyAntineoplastic Combined Chemotherapy ProtocolsBiopsy, Fine-NeedleCarcinoma, MedullaryCarcinoma, NeuroendocrineDisease ManagementGenetic TestingHormone Replacement TherapyHumansMultiple Endocrine Neoplasia Type 2aMultiple Endocrine Neoplasia Type 2bProto-Oncogene Proteins c-retRadiotherapySocieties, MedicalThyroid NeoplasmsProto-Oncogene Proteins c-retRET protein, human

Identifiers

PMID25810047
PMCPMC4490627

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.