ArticleJournal of clinical microbiology2015
What Is the Origin of Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Isolates from Humans without Livestock Contact? An Epidemiological and Genetic Analysis.
Article in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Article
- Antimicrobial Susceptibility Profiles and Molecular Characterisation ofAntibiotics (Basel, Switzerland) · 2022Article
- Antimicrobial Resistance and Molecular Epidemiology ofPathogens (Basel, Switzerland) · 2022Article
- Livestock-associated methicillin-resistantFrontiers in microbiology · 2022Article
- HumanMicroorganisms · 2020Review
- Livestock-associated methicillin-resistantJournal of veterinary science · 2020Article
- Genome investigations show host adaptation and transmission of LA-MRSA CC398 from pigs into Danish healthcare institutions.Scientific reports · 2019Article
- Genome Sequences of Livestock-Associated Methicillin-Resistant Staphylococcus aureusMicrobiology resource announcements · 2019Article
- Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology.Clinical microbiology reviews · 2018Review
- Prevalence and Genomic Structure of Bacteriophage phi3 in Human-Derived Livestock-Associated Methicillin-Resistant Staphylococcus aureus Isolates from 2000 to 2015.Journal of clinical microbiology · 2018Article
- CC398 Staphylococcus aureus subpopulations in Belgian patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Distance to pig farms as risk factor for community-onset livestock-associated MRSA CC398 infection in persons without known contact to pig farms-A nationwide study.Zoonoses and public health · 2018Article
- Bacteria from Animals as a Pool of Antimicrobial Resistance Genes.Antibiotics (Basel, Switzerland) · 2017Review
- The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2015.EFSA journal. European Food Safety Authority · 2017Article
- Molecular Epidemiology of Staphylococcus aureus among Patients with Skin and Soft Tissue Infections in Two Chinese Hospitals.Chinese medical journal · 2016Article
- Fatal Septicemia Linked to Transmission of MRSA Clonal Complex 398 in Hospital and Nursing Home, Denmark.Emerging infectious diseases · 2016Article
- The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2014.EFSA journal. European Food Safety Authority · 2016Article
- Livestock-Associated MRSA: The Impact on Humans.Antibiotics (Basel, Switzerland) · 2015Review
- Article
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fifteen percent of all methicillin-resistant Staphylococcus aureus (MRSA) clonal complex 398 (CC398) human carriers detected in The Netherlands had not been in direct contact with pigs or veal calves. To ensure low MRSA prevalence, it is important to investigate the likely origin of this MRSA of unknown origin (MUO). Recently, it was shown that CC398 strains originating from humans and animals differ in the presence of specific mobile genetic elements (MGEs). We hypothesized that determining these specific MGEs in MUO isolates and comparing them with a set of CC398 isolates of various known origin might provide clues to their origin. MUO CC398 isolates were compared to MRSA CC398 isolates obtained from humans with known risk factors, a MRSA CC398 outbreak isolate, livestock associated (LA) MRSA CC398 isolates from pigs, horses, chickens, and veal calves, and five methicillin-susceptible Staphylococcus aureus (MSSA) CC398 isolates of known human origin. All strains were spa typed, and the presence or absence of, scn, chp, φ3 int, φ6 int, φ7 int, rep7, rep27, and cadDX was determined by PCRs. The MRSA CC398 in humans, MUO, or MRSA of known origin (MKO) resembled MRSA CC398 as found in pigs and not MSSA CC398 as found in humans. The distinct human MSSA CC398 spa type, t571, was not present among our MRSA CC398 strains; MRSA CC398 was tetracycline resistant and carried no φ3 bacteriophage with scn and chp. We showed by simple PCR means that human MUO CC398 carriers carried MRSA from livestock origin, suggestive of indirect transmission. Although the exact transmission route remains unknown, direct human-to-human transmission remains a possibility as well.
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