ArticleThe Journal of physiology2015
Extensor motoneurone properties are altered immediately before and during fictive locomotion in the adult decerebrate rat.
Article in The Journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Age-Related Differences in Corticospinal Function and Muscle Strength: A Systematic Review and Meta-Analysis.The European journal of neuroscience · 2026Pooled it
- Ascending propriospinal modulation of thoracic sympathetic preganglionic neurons during lumbar locomotor activity.Frontiers in neural circuits · 2026Article
- Exercise-induced adaptation of neurons in the vertebrate locomotor system.Journal of sport and health science · 2024Review
- Signaling pathways regulated by natural active ingredients in the fight against exercise fatigue-a review.Frontiers in pharmacology · 2023Review
- The electrophysiological properties of hindlimb motoneurons do not differ between male and female rats.The European journal of neuroscience · 2022Article
- Endurance-exercise training adaptations in spinal motoneurones: potential functional relevance to locomotor output and assessment in humans.European journal of applied physiology · 2022Review
- The effects of membrane potential oscillations on the excitability of rat hypoglossal motoneurons.Frontiers in physiology · 2022Article
- Locomotor Pattern and Force Generation Modulated by Ionic Channels: A Computational Study of Spinal Networks Underlying Locomotion.Frontiers in computational neuroscience · 2022Article
- Article
- Corticospinal-Evoked Responses from the Biceps Brachii during Arm Cycling across Multiple Power Outputs.Brain sciences · 2019Article
- Retracing your footsteps: developmental insights to spinal network plasticity following injury.Journal of neurophysiology · 2018Review
- Influence of Brain Stem on Axial and Hindlimb Spinal Locomotor Rhythm Generating Circuits of the Neonatal Mouse.Frontiers in neuroscience · 2018Article
- α-Motoneurons maintain biophysical heterogeneity in obesity and diabetes in Zucker rats.Journal of neurophysiology · 2017Article
- Spike threshold dynamics in spinal motoneurons during scratching and swimming.The Journal of physiology · 2017Article
- Serotonin controls initiation of locomotion and afferent modulation of coordination via 5-HTThe Journal of physiology · 2017Article
- Monoamine Release in the Cat Lumbar Spinal Cord during Fictive Locomotion Evoked by the Mesencephalic Locomotor Region.Frontiers in neural circuits · 2017Article
- LFP Oscillations in the Mesencephalic Locomotor Region during Voluntary Locomotion.Frontiers in neural circuits · 2017Article
- Nonreciprocal mechanisms in up- and downregulation of spinal motoneuron excitability by modulators of KCNQ/Kv7 channels.Journal of neurophysiology · 2016Article
- Irregular Firing and High-Conductance States in Spinal Motoneurons during Scratching and Swimming.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Cadence-dependent changes in corticospinal excitability of the biceps brachii during arm cycling.Journal of neurophysiology · 2015Article
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Authors and funding
5 authors.
Funding
Abstract
This study examined motoneurone properties during fictive locomotion in the adult rat for the first time. Fictive locomotion was induced via electrical stimulation of the mesencephalic locomotor region in decerebrate adult rats under neuromuscular blockade to compare basic and rhythmic motoneurone properties in antidromically identified extensor motoneurones during: (1) quiescence, before and after fictive locomotion; (2) the 'tonic' period immediately preceding locomotor-like activity, whereby the amplitude of peripheral flexor (peroneal) and extensor (tibial) nerves are increased but alternation has not yet occurred; and (3) locomotor-like episodes. Locomotion was identified by alternating flexor-extensor nerve activity, where the motoneurone either produced membrane oscillations consistent with a locomotor drive potential (LDP) or did not display membrane oscillation during alternating nerve activity. Cells producing LDPs were referred to as such, while those that did not were referred to as 'idle' motoneurones. LDP and idle motoneurones during locomotion had hyperpolarized spike threshold (Vth ; LDP: 3.8 mV; idle: 5.8 mV), decreased rheobase and an increased discharge rate (LDP: 64%; idle: 41%) during triangular ramp current injection even though the frequency-current slope was reduced by 70% and 55%, respectively. Modulation began in the tonic period immediately preceding locomotion, with a hyperpolarized Vth and reduced rheobase. Spike frequency adaptation did not occur in spiking LDPs or firing generated from sinusoidal current injection, but occurred during a sustained current pulse during locomotion. Input conductance showed no change. Results suggest motoneurone modulation occurs across the pool and is not restricted to motoneurones engaged in locomotion.
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