ReviewAnnals of the New York Academy of Sciences2015
Rhythms and blues: modulation of oscillatory synchrony and the mechanism of action of antidepressant treatments.
Review in Annals of the New York Academy of Sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04019054 (Transcranial Magnetic Stimulation), which is not on this map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transcranial Magnetic Stimulation (TMS) in Conjunction With Exposure Therapy for the Treatment of Spider Phobia
Who cites it
27 citing papers in PubMed, 71 citations in OpenAlex.
- Clinical effects of continuous theta burst stimulation for generalized anxiety disorder and a mechanism involving α oscillations: a randomized controlled trial.Journal of psychiatry & neuroscience : JPNTrial
- Neuromodulation of Fear and Anxiety Circuits.Current topics in behavioral neurosciences · 2025Review
- Age, Dose, and Locomotion: Decoding Vulnerability to Ketamine in C57BL/6J and BALB/c Mice.Biomedicines · 2023Article
- Network-specific metabolic and haemodynamic effects elicited by non-invasive brain stimulation.Nature. Mental health · 2023Article
- Treatment of Spider Phobia Using Repeated Exposures and Adjunctive Repetitive Transcranial Magnetic Stimulation: A Proof-of-Concept Study.Frontiers in psychiatry · 2022Article
- Editorial: Oscillotherapeutics - toward real-time control of pathological oscillations in the brain.Frontiers in behavioral neuroscience · 2022Article
- Yijinjing Qigong intervention shows strong evidence on clinical effectiveness and electroencephalography signal features for early poststroke depression: A randomized, controlled trial.Frontiers in aging neuroscience · 2022Article
- Psychiatric Applications of Repetitive Transcranial Magnetic Stimulation.Focus (American Psychiatric Publishing) · 2022Review
- Deep brain stimulation for psychiatric disorders: From focal brain targets to cognitive networks.NeuroImage · 2021Review
- Temporally Targeted Interactions With Pathologic Oscillations as Therapeutical Targets in Epilepsy and Beyond.Frontiers in neural circuits · 2021Review
- Theta-Range Oscillations in Stress-Induced Mental Disorders as an Oscillotherapeutic Target.Frontiers in behavioral neuroscience · 2021Review
- Experimental evaluation of methods for real-time EEG phase-specific transcranial magnetic stimulation.Journal of neural engineering · 2020Article
- Prospective testing of a neurophysiologic biomarker for treatment decisions in major depressive disorder: The PRISE-MD trial.Journal of psychiatric research · 2020Article
- Device-Based Modulation of Neurocircuits as a Therapeutic for Psychiatric Disorders.Annual review of pharmacology and toxicology · 2020Review
- Changes in Functional Connectivity Predict Outcome of Repetitive Transcranial Magnetic Stimulation Treatment of Major Depressive Disorder.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Time Course of Changes in Peripheral Blood Gene Expression During Medication Treatment for Major Depressive Disorder.Frontiers in genetics · 2019Article
- A Pilot Study Investigating the Effect of Music-Based Intervention on Depression and Anhedonia.Frontiers in psychology · 2019Article
- Updates on Transcranial Magnetic Stimulation Therapy for Major Depressive Disorder.The Psychiatric clinics of North America · 2018Review
- Imaging TMS: antidepressant mechanisms and treatment optimization.International review of psychiatry (Abingdon, England) · 2017Review
- Network-Guided Transcranial Magnetic Stimulation for Depression.Current behavioral neuroscience reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Treatments for major depressive disorder (MDD) act at different hierarchical levels of biological complexity, ranging from the individual synapse to the brain as a whole. Theories of antidepressant medication action traditionally have focused on the level of cell-to-cell interaction and synaptic neurotransmission. However, recent evidence suggests that modulation of synchronized electrical activity in neuronal networks is a common effect of antidepressant treatments, including not only medications, but also neuromodulatory treatments such as repetitive transcranial magnetic stimulation. Synchronization of oscillatory network activity in particular frequency bands has been proposed to underlie neurodevelopmental and learning processes, and also may be important in the mechanism of action of antidepressant treatments. Here, we review current research on the relationship between neuroplasticity and oscillatory synchrony, which suggests that oscillatory synchrony may help mediate neuroplastic changes related to neurodevelopment, learning, and memory, as well as medication and neuromodulatory treatment for MDD. We hypothesize that medication and neuromodulation treatments may have related effects on the rate and pattern of neuronal firing, and that these effects underlie antidepressant efficacy. Elucidating the mechanisms through which oscillatory synchrony may be related to neuroplasticity could lead to enhanced treatment strategies for MDD.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.