Evidence map›Paper›PMID 25809707›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2015

Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma.

Hong-Fang Duan, Xiao-Qing Li, Hong-Yi Hu, Yu-Chi Li, Zhi Cai, Xue-Shuang Mei, Peng Yu, Li-Ping Nie, Wei Zhang, Zhen-Dong Yu and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  15. miR-214 inhibits invasion and migration via downregulating GALNT7 in esophageal squamous cell cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  16. GALNT7, a target of miR-494, participates in the oncogenesis of nasopharyngeal carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  17. Review
  18. Expression and clinical evidence of miR-494 and PTEN in non-small cell lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Hong-Fang DuanDepartment of Otolaryngological, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
Xiao-Qing LiDepartment of Clinical Laboratory, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
Hong-Yi HuDepartment of Otolaryngological, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
Yu-Chi LiShantou University Medical College, 515041, Shantou, Guangdong Province, China.
Zhi CaiDepartment of Otolaryngological, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
Xue-Shuang MeiDepartment of Otolaryngological, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
Peng YuDepartment of Otolaryngological, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
Li-Ping NieDepartment of Clinical Laboratory, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
Wei ZhangBiomedical Research Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, 518036, Shenzhen, Guangdong Province, China. zhangweispace@yeah.net.
Zhen-Dong YuCentral Laboratory, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China. dongboyaa@163.com.
Guo-Hui NieDepartment of Otolaryngological, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China. nghui@21cn.com.
Peking University Shenzhen Hospital · CNGuangzhou Medical University · CNShantou University · CNUniversity of Hong Kong - Shenzhen Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nasopharyngeal carcinoma has very high incidence and high mortality worldwide. MiRNA is related to the tumorigenesis and metastasis of a variety of tumors. In the present study, we verify that the expression of miR-494 in NPC tissues and NPC-derived cells was down-regulated, respectively. The proliferation, colony formation, migration, and invasion of NPC-derived cells were suppressed, while the cell apoptosis was promoted, when miR-494 was over-expressed in these cells. GALNT7 and CDK16 were confirmed to be the direct targets of miR-494. These results suggested that miR-494 play an inhibitory role in the tumorigenesis of NPC.

Indexed as

ApoptosisCarcinogenesisCarcinomaCell Line, TumorCell ProliferationCyclin-Dependent KinasesGene Expression Regulation, NeoplasticHumansMicroRNAsN-AcetylgalactosaminyltransferasesNasopharyngeal CarcinomaNasopharyngeal NeoplasmsNeoplasm InvasivenessRNA, MessengerCyclin-Dependent KinasesMicroRNAsMIRN494 microRNA, humanN-AcetylgalactosaminyltransferasesPCTAIRE-1 protein kinaseRNA, MessengerUDP-N-acetylgalactosamine--polypeptide N-acetylgalactosaminyltransferase 7CDK16GALNT7miR-494Nasopharyngeal carcinomaTumor suppressor

Identifiers

PMID25809707
PMCPMC4644213
OpenAlexW1965834587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.