Evidence map›Paper›PMID 25809631›Full record

ArticleClinical and vaccine immunology : CVI2015

Induction of potent adaptive immunity by the novel polyion complex nanoparticles.

Tomofumi Uto, Takami Akagi, Mitsuru Akashi, Masanori Baba

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Polymeric Nanoparticle-Based Vaccine Adjuvants and Delivery Vehicles.Current topics in microbiology and immunology · 2021
    Review
  2. Biodegradable polymers for modern vaccine development.Journal of industrial and engineering chemistry (Seoul, Korea) · 2019
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Tomofumi UtoDivision of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan Core Research for Evolutional Science and Technology (CREST), the Japan Science and Technology Agency (JST), Tokyo, Japan.
Takami AkagiDepartment of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Japan Core Research for Evolutional Science and Technology (CREST), the Japan Science and Technology Agency (JST), Tokyo, Japan.
Mitsuru AkashiDepartment of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Japan Core Research for Evolutional Science and Technology (CREST), the Japan Science and Technology Agency (JST), Tokyo, Japan.
Masanori BabaDivision of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan Core Research for Evolutional Science and Technology (CREST), the Japan Science and Technology Agency (JST), Tokyo, Japan m-baba@m2.kufm.kagoshima-u.ac.jp.
Japan Science and Technology Agency · JPKagoshima University · JPOsaka University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of effective and simple methods of vaccine preparation is desired for the prophylaxis and treatment of a variety of infectious diseases and cancers. We have created novel polyion complex (PIC) nanoparticles (NPs) composed of amphiphilic anionic biodegradable poly(γ-glutamic acid) (γ-PGA) and cationic polymers as a vaccine adjuvant. PIC NPs can be prepared by mixing γ-PGA-graft-l-phenylalanine ethylester (γ-PGA-Phe) polymer with cationic polymer in phosphate-buffered saline. We examined the efficacy of PIC NPs for antigen delivery and immunostimulatory activity in vitro and in vivo. PIC NPs enhanced the uptake of ovalbumin (OVA) by dendritic cells (DCs) and subsequently induced DC maturation. The immunization of mice with OVA-carrying PIC NPs induced potent and antigen-specific cellular and humoral immunity. Since PIC NPs can be created with water-soluble anionic γ-PGA-Phe and a cationic polymer by simple mixing in the absence of any organic solvents, PIC NPs may have potential as a novel candidate for an effective antigen carrier and vaccine adjuvant.

Indexed as

Adaptive ImmunityAdjuvants, ImmunologicAnimalsAntigensCD40 AntigensCytokinesDendritic CellsFemaleImmunity, CellularMice, Inbred C57BLNanoparticlesOvalbuminPolyglutamic AcidAdjuvants, ImmunologicAntigensCD40 AntigensCytokinesOvalbuminpoly(gamma-glutamic acid)Polyglutamic Acid

Identifiers

PMID25809631
PMCPMC4412939
OpenAlexW2321807500

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.