ArticleInternational journal of molecular sciences2015
Characterization and antihyperglycemic activity of a polysaccharide from Dioscorea opposita Thunb roots.
Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Additional Benefit of Chinese Medicine Formulae IncludingFrontiers in endocrinology · 2020Pooled it
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- Bioactive Metabolites ofFoods (Basel, Switzerland) · 2025Review
- Traditional Chinese medicine for HIV-related chronic comorbidities: evidence and potential therapeutic mechanisms.Frontiers in pharmacology · 2025Review
- Anti-obesity effects exerted byFood science & nutrition · 2023Article
- Isolation, Structural Characteristics Analysis of aMolecules (Basel, Switzerland) · 2023Article
- Effects of dietaryFrontiers in veterinary science · 2023Article
- The Therapeutic Potential of Plant Polysaccharides in Metabolic Diseases.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Molecular Mechanisms Underlying Qi-Invigorating Effects in Traditional Medicine: Network Pharmacology-Based Study on the Unique Functions of Qi-Invigorating Herb Group.Plants (Basel, Switzerland) · 2022Article
- Structures and Anti-Inflammatory Evaluation of Phenylpropanoid Derivatives from the Aerial Parts ofInternational journal of molecular sciences · 2022Article
- AInternational journal of molecular sciences · 2022Article
- Review
- Metabolome Profiling of Eight Chinese Yam (Life (Basel, Switzerland) · 2021Article
- YiQi YangYin Decoction Attenuates Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Rats.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Review
- Pharmacodynamic material basis of traditional Chinese medicine based on biomacromolecules: a review.Plant methods · 2020Review
- Potential of Neglected and Underutilized Yams (Frontiers in pharmacology · 2020Review
- YiqiHuoxue Decoction and Its Ethanol Precipitation Show Anti-Platelet and Antithrombotic Effects by Suppressing Thromboxane B2 Formation.Acta Cardiologica Sinica · 2019Article
- Understanding the Role of the Gut Microbiome and Microbial Metabolites in Obesity and Obesity-Associated Metabolic Disorders: Current Evidence and Perspectives.Current obesity reports · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A polysaccharide DOTP-80 from Dioscorea opposita Thunb was obtained by using the method of acid water-extraction and ethanol-precipitation. After being purified by chromatography, the structure characteristics of DOTP-80 were established. Based on the calibration curve obtained with standard dextrans, the molecular weight of the polysaccharide fraction DOTP-80 was calculated to be 123 kDa. The results of Infrared spectrum (FT-IR) indicated that the polysaccharide contained the α-configuration of sugar units. GC-MS analysis revealed that DOTP-80 was mainly composed of mannose and glucose. Alloxan-induced diabetic rats and mice models were developed to evaluate the in vivo hypoglycemic activity of the polysaccharide. The results indicated that a high dose DOTP-80 (400 mg/kg) had strong hypoglycemic activity. Moreover, DOTP-80 could increase the level of antioxidant enzymes (SOD) activity in alloxan-induced diabetic mice and stimulate an increase in glucose disposal in diabetic rats. Therefore, the polysaccharide DOTP-80 should be evaluated as a candidate for future studies on diabetes mellitus.
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