ArticleInternational journal of molecular sciences2015
Supramolecular cationic assemblies against multidrug-resistant microorganisms: activity and mechanism of action.
Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Colloidal Dispersions of Gramicidin D in Water: Preparation, Characterization, and Differential Cytotoxicity.ACS omega · 2025Article
- Emerging Cationic Nanovaccines.Pharmaceutics · 2024Review
- Transient Coatings from Nanoparticles Achieving Broad-Spectrum and High Antimicrobial Performance.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Characterization and Differential Cytotoxicity of Gramicidin Nanoparticles Combined with Cationic Polymer or Lipid Bilayer.Pharmaceutics · 2022Article
- Antimicrobial Polymer-Based Assemblies: A Review.International journal of molecular sciences · 2021Review
- Article
- Effect of DODAB Nano-Sized Cationic Bilayer Fragments againstMolecules (Basel, Switzerland) · 2020Article
- Cationic Nanostructures for Vaccines Design.Biomimetics (Basel, Switzerland) · 2020Review
- Positively Charged Polymers as Promising Devices against Multidrug Resistant Gram-Negative Bacteria: A Review.Polymers · 2020Review
- Simple Nanoparticles from the Assembly of Cationic Polymer and Antigen as Immunoadjuvants.Vaccines · 2020Article
- Biomimetic antimicrobial material strategies for combating antibiotic resistant bacteria.Biomaterials science · 2020Review
- Microbicidal Dispersions and Coatings from Hybrid Nanoparticles of Poly (Methyl Methacrylate), Poly (Diallyl Dimethyl Ammonium) Chloride, Lipids, and Surfactants.International journal of molecular sciences · 2019Article
- Antimicrobial Coatings from Hybrid Nanoparticles of Biocompatible and Antimicrobial Polymers.International journal of molecular sciences · 2018Article
- Self-Assembled Antimicrobial Nanomaterials.International journal of environmental research and public health · 2018Review
- Cationic Biomimetic Particles of Polystyrene/Cationic Bilayer/Gramicidin for Optimal Bactericidal Activity.Nanomaterials (Basel, Switzerland) · 2017Article
- Cationic Nanostructures against Foodborne Pathogens.Frontiers in microbiology · 2016Article
- The antimicrobial activity of free and immobilized poly (diallyldimethylammonium) chloride in nanoparticles of poly (methylmethacrylate).Journal of nanobiotechnology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The growing challenge of antimicrobial resistance to antibiotics requires novel synthetic drugs or new formulations for old drugs. Here, cationic nanostructured particles (NPs) self-assembled from cationic bilayer fragments and polyelectrolytes are tested against four multidrug-resistant (MDR) strains of clinical importance. The non-hemolytic poly(diallyldimethylammonium) chloride (PDDA) polymer as the outer NP layer shows a remarkable activity against these organisms. The mechanism of cell death involves bacterial membrane lysis as determined from the leakage of inner phosphorylated compounds and possibly disassembly of the NP with the appearance of multilayered fibers made of the NP components and the biopolymers withdrawn from the cell wall. The NPs display broad-spectrum activity against MDR microorganisms, including Gram-negative and Gram-positive bacteria and yeast.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.