SynthesisHypertension research : official journal of the Japanese Society of Hypertension2015
Treatment-induced changes in ambulatory arterial stiffness index: one-year prospective study and meta-analysis of evidence.
Synthesis in Hypertension research : official journal of the Japanese Society of Hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- End Point-Based Threshold for the Ambulatory Arterial Stiffness Index.Hypertension (Dallas, Tex. : 1979) · 2026Pooled it
- Ambulatory arterial stiffness index, mortality, and adverse cardiovascular outcomes; Systematic review and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2024Pooled it
- Effects of a 4-Week Multi-Exercise Isometric Resistance Training Programme on Resting and Ambulatory Blood Pressure in Normotensive Adults.European journal of sport science · 2026Trial
- The Relationship Between Ambulatory Arterial Stiffness Index and Cardiovascular Outcomes in Women.Cardiology research · 2021Article
- New approach to arterial stiffness: BP-independent local carotid stiffness.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Cardiovascular calcification and subcortical bone demineralization in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Second derivative of the finger photoplethysmogram and cardiovascular mortality in middle-aged and elderly Japanese women.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Influence of the central-to-peripheral arterial stiffness gradient on the timing and amplitude of wave reflections.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- Ambulatory arterial stiffness in chronic kidney disease: a methodological review.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Review
- The Use of the Ambulatory Arterial Stiffness Index in Patients Suspected of Secondary Hypertension.Frontiers in cardiovascular medicine · 2016Article
- Is ambulatory arterial stiffness index a marker of large-artery stiffness? Evidence from intervention studies.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
Corrections and comments
- Commented on by
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ambulatory arterial stiffness index (AASI) has been introduced as an index of arterial function, predicting cardiovascular events. However, treatment-induced changes in AASI are rather equivocal. This study aims to: (i) present the results of treatment-induced changes in AASI in untreated subjects with elevated blood pressure (BP), subjected to antihypertensive treatment for 1 year and (ii) perform a meta-analysis of studies reporting on treatment-induced change in AASI. A total of 104 subjects (mean age 51.4±10.3 years, 62% males, mean follow-up: 13.6±2.4 months) were analyzed. Despite significant reductions in 24-h ambulatory systolic/diastolic BP, pulse pressure and pulse wave velocity (mean change: -15.9±12/-10.4±7.6 mm Hg, -5.4±6.8 mm Hg, -0.7±1.9 m s(-1), respectively, all P<0.05), there was no significant change (Follow up-Baseline) in AASI values (mean change: 0.01±0.17, P=not significant). The treatment-induced change in AASI was correlated with baseline AASI (r=-0.61), baseline 24-h pulse pressure (-0.26), treatment-induced change in 24-h pulse pressure (0.26) and in systolic/diastolic nocturnal dipping (-0.25/-0.40, respectively). Meta-analysis of eight trials (n=990) revealed a marginal decrease in AASI with antihypertensive treatment (pooled change: -0.018 (95% confidence interval (CI): -0.033,-0.003)). When the analysis was restricted to data with renin-angiotensin system blockers (n=755, 76% of total), the results did not significantly change (pooled change -0.028 (95% CI -0.048, -0.007)). In conclusion, although AASI is an independent predictor of cardiovascular events, its response to antihypertensive treatment is only marginal and clinically uncertain, which may render its use as a therapeutic target in clinical practice questionable.
Indexed as
Identifiers
25809579What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.