ArticleEvolution; international journal of organic evolution2015
The cost of phage resistance in a plant pathogenic bacterium is context-dependent.
Article in Evolution; international journal of organic evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 85 citations in OpenAlex.
- Bacteriophage-bacteria coevolution: from molecular arms races to ecological and applied perspectives.Archives of microbiology · 2026Review
- The role of phages in plant-associated microbial communities.Essays in biochemistry · 2026Review
- Bacteriophage Density Influences the Rate of Resistance Evolution.Bulletin of mathematical biology · 2026Article
- Phages tame plant pathogens.Nature microbiology · 2026Article
- Life strategies of bacterial taxa in rearing water microbiomes of whiteleg shrimp (Litopenaeus vannamei) larviculture.World journal of microbiology & biotechnology · 2026Article
- Phage Therapy in Plant Disease Management: 110 Years of History, Current Challenges, and Future Trends.Plants (Basel, Switzerland) · 2026Review
- Limitations and safety aspects related to the use of bacteriophages in food production.FEMS microbiology reviews · 2026Article
- Artificial intelligence-driven phage therapy in veterinary medicine: an adaptive One Health strategy to mitigate antimicrobial resistance in livestock systems.Frontiers in veterinary science · 2026Review
- Unveiling Host Interactions and Evolutionary Constraints of a Novel Bacteriophage Infecting Xanthomonas hortorum pv. vitians.Environmental microbiology reports · 2025Article
- Genomic correlates of tailocin sensitivity in Pseudomonas syringae.G3 (Bethesda, Md.) · 2025Article
- Reprogramming resistance: phage-antibiotic synergy targets efflux systems in ESKAPEE pathogens.mBio · 2025Review
- Bacteriophage density influences the rate of resistance evolution.bioRxiv : the preprint server for biology · 2025Article
- Abiotic environmental conditions determine phage resistance outcomes in a salt-marsh bacterium.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Review
- Survival and spread of engineeredApplied and environmental microbiology · 2025Article
- Bacteria-phage (co)evolution is constrained in a synthetic community across multiple bacteria-phage pairs.Microbiology (Reading, England) · 2025Article
- Harnessing Bacteriophages for Sustainable Crop Protection in the Face of Climate Change.Microbial biotechnology · 2025Review
- Long-term metagenomic insights into the roles of antiviral defense systems in stabilizing activated sludge bacterial communities.The ISME journal · 2025Article
- Community Trait Variation Drives Selection on Species Diversity Through Feedback With Predator Density.Ecology and evolution · 2024Article
- Development of phage-containing hydrogel for treating Enterococcus faecalis-infected wounds.PloS one · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parasites are ubiquitous features of living systems and many parasites severely reduce the fecundity or longevity of their hosts. This parasite-imposed selection on host populations should strongly favor the evolution of host resistance, but hosts typically face a trade-off between investment in reproductive fitness and investment in defense against parasites. The magnitude of such a trade-off is likely to be context-dependent, and accordingly costs that are key in shaping evolution in nature may not be easily observable in an artificial environment. We set out to assess the costs of phage resistance for a plant pathogenic bacterium in its natural plant host versus in a nutrient-rich, artificial medium. We demonstrate that mutants of Pseudomonas syringae that have evolved resistance via a single mutational step pay a substantial cost for this resistance when grown on their tomato plant hosts, but do not realize any measurable growth rate costs in nutrient-rich media. This work demonstrates that resistance to phage can significantly alter bacterial growth within plant hosts, and therefore that phage-mediated selection in nature is likely to be an important component of bacterial pathogenicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.