ArticleNature communications2015
Fundamental origins and limits for scaling a maternal morphogen gradient.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Embryonic scaling: morphogen gradients, size sensing, and scaler genes.Frontiers in cell and developmental biology · 2026Review
- Rapid response of fly populations to gene dosage across development and generations.Nature communications · 2024Article
- Article
- Size regulation of the lateral organ initiation zone and its role in determining cotyledon number in conifers.Frontiers in plant science · 2023Article
- Modeling Obesity-Associated Ovarian Dysfunction inNutrients · 2022Article
- Two-stage patterning dynamics in conifer cotyledon whorl morphogenesis.Annals of botany · 2018Article
- Mechanisms and Measurements of Scale Invariance of Morphogen Gradients.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Embryoids, organoids and gastruloids: new approaches to understanding embryogenesis.Development (Cambridge, England) · 2017Review
- LncRNA mediated regulation of aging pathways inAging · 2016Article
- Article
- Temporal and spatial dynamics of scaling-specific features of a gene regulatory network in Drosophila.Nature communications · 2015Article
- Modulation of temporal dynamics of gene transcription by activator potency in the Drosophila embryo.Development (Cambridge, England) · 2015Article
- Probing the impact of temperature on molecular events in a developmental system.Scientific reports · 2015Article
- Read-Out of Dynamic Morphogen Gradients on Growing Domains.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Tissue expansion and patterning are integral to development; however, it is unknown quantitatively how a mother accumulates molecular resources to invest in the future of instructing robust embryonic patterning. Here we develop a model, Tissue Expansion-Modulated Maternal Morphogen Scaling (TEM(3)S), to study scaled anterior-posterior patterning in Drosophila embryos. Using both ovaries and embryos, we measure a core quantity of the model, the scaling power of the Bicoid (Bcd) morphogen gradient's amplitude nA. We also evaluate directly model-derived predictions about Bcd gradient and patterning properties. Our results show that scaling of the Bcd gradient in the embryo originates from, and is constrained fundamentally by, a dynamic relationship between maternal tissue expansion and bcd gene copy number expansion in the ovary. This delicate connection between the two transitioning stages of a life cycle, stemming from a finite value of nA~3, underscores a key feature of developmental systems depicted by TEM(3)S.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.