ArticleSocial cognitive and affective neuroscience2015
Neural correlates of aberrant emotional salience predict psychotic symptoms and global functioning in high-risk and first-episode psychosis.
Article in Social cognitive and affective neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05282277 (Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Neural correlates of emotional processing in psychosis risk and onset - A systematic review and meta-analysis of fMRI studies.Neuroscience and biobehavioral reviews · 2021Pooled it
- A single dose of cannabidiol modulates medial temporal and striatal function during fear processing in people at clinical high risk for psychosis.Translational psychiatry · 2020Trial
- Longitudinal association between neighborhood-level social capital and incidence of major psychiatric disorders in a cohort of 1.4 million people in Sweden.Nature. Mental health · 2025Article
- Psychotic Arousal and the Psychopathology of Acute Schizophrenia: An Exploratory Study of the Experiential Emotional State in Acute Psychosis.Journal of clinical medicine · 2024Article
- Abnormal ambiguous facial expression recognition in Chinese patients with schizophrenia.BMC psychiatry · 2024Article
- Clinical high risk for psychosis syndrome is associated with reduced neural responding to unpleasant images.Journal of psychopathology and clinical science · 2023Article
- Sex and pubertal influences on the neurodevelopmental underpinnings of schizophrenia: A case for longitudinal research on adolescents.Schizophrenia research · 2023Review
- Brain activity changes with emotional words in different stages of psychosis.European psychiatry : the journal of the Association of European Psychiatrists · 2022Article
- Aberrant salience correlates with psychotic dimensions in outpatients with schizophrenia spectrum disorders.Annals of general psychiatry · 2022Article
- Neural Correlates of Facial Emotion Recognition in Non-help-seeking University Students With Ultra-High Risk for Psychosis.Frontiers in psychology · 2022Article
- Multivariate Analysis of Structural and Functional Neuroimaging Can Inform Psychiatric Differential Diagnosis.Diagnostics (Basel, Switzerland) · 2020Article
- Structural and functional imaging markers for susceptibility to psychosis.Molecular psychiatry · 2020Review
- Neural Circuitry of Novelty Salience Processing in Psychosis Risk: Association With Clinical Outcome.Schizophrenia bulletin · 2020Article
- Association of Adverse Outcomes With Emotion Processing and Its Neural Substrate in Individuals at Clinical High Risk for Psychosis.JAMA psychiatry · 2020Article
- Atypical processing of uncertainty in individuals at risk for psychosis.NeuroImage. Clinical · 2020Article
- Article
- Basic Self-Disturbances Related to Reduced Anterior Cingulate Volume in Subjects at Ultra-High Risk for Psychosis.Frontiers in psychiatry · 2019Article
- Aberrant Salience Across Levels of Processing in Positive and Negative Schizotypy.Frontiers in psychology · 2019Article
- Resting state connectivity dynamics in individuals at risk for psychosis.Journal of abnormal psychology · 2018Article
- Ventral Striatal Dysfunction and Symptom Expression in Individuals With Schizotypal Personality Traits and Early Psychosis.Schizophrenia bulletin · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurobiological and behavioral findings suggest that psychosis is associated with corticolimbic hyperactivity during the processing of emotional salience. This has not been widely studied in the early stages of psychosis, and the impact of these abnormalities on psychotic symptoms and global functioning is unknown. We sought to address this issue in 18 patients with first-episode psychosis (FEP), 18 individuals at ultra high risk of psychosis (UHR) and 22 healthy controls (HCs). Corticolimbic response and subjective ratings to emotional and neutral scenes were measured using functional magnetic resonance imaging. The clinical and functional impact of corticolimbic abnormalities was assessed with regression analyses. The FEP and UHR groups reported increased subjective emotional arousal to neutral scenes compared with HCs. Across groups, emotional vs neutral scenes elicited activation in the dorsomedial prefrontal cortex, inferior frontal gyrus/anterior insula and amygdala. Although FEP and UHR participants showed reduced activation in these regions when viewing emotional scenes compared with controls, this was driven by increased activation to neutral scenes. Corticolimbic hyperactivity to neutral scenes predicted higher levels of positive symptoms and poorer levels of functioning. These results indicate that disruption of emotional brain systems may represent an important biological substrate for the pathophysiology of early psychosis and UHR states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.