ArticleProceedings. Biological sciences2015
Susceptibility of amphibians to chytridiomycosis is associated with MHC class II conformation.
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 149 citations in OpenAlex.
- Genomic Correlates of Disease Recovery in Natural Populations of the Sierra Nevada Yellow-Legged Frog (Rana sierrae).Molecular ecology · 2026Article
- Selection of geographical populations suitable for artificial breeding of the Northeast China Brown Frog (Rana dybowskii).Die Naturwissenschaften · 2025Article
- Mitigation of chytridiomycosis onMicrobiology spectrum · 2025Article
- Host and environmental factors drive prevalence of the pathogen Batrachochytrium dendrobatidis in Central African amphibians.Scientific reports · 2025Article
- Amphibian (Journal of fungi (Basel, Switzerland) · 2025Article
- MHC Diversity Across Time and Space.Ecology and evolution · 2025Review
- Quantifying intraspecific variation in host resistance and tolerance to a lethal pathogen.The Journal of animal ecology · 2025Article
- Koala MHCII association with chlamydia infertility remains equivocal: a need for new research approaches.Scientific reports · 2024Article
- The Amphibian Genomics Consortium: advancing genomic and genetic resources for amphibian research and conservation.BMC genomics · 2024Review
- The Amphibian Genomics Consortium: advancing genomic and genetic resources for amphibian research and conservation.bioRxiv : the preprint server for biology · 2024Article
- Batrachochytrium dendrobatidis strain affects transcriptomic response in liver but not skin in latitudinal populations of the common toad (Bufo bufo).Scientific reports · 2024Article
- Chytrid infections exhibit historical spread and contemporary seasonality in a declining stream-breeding frog.Royal Society open science · 2024Article
- Metabolites of Xenorhabdus bacteria are potent candidates for mitigating amphibian chytridiomycosis.AMB Express · 2023Article
- Amphibian infection tolerance to chytridiomycosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- The amphibian immune system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Conserved Evolution of MHC Supertypes among Japanese Frogs Suggests Selection for Bd Resistance.Animals : an open access journal from MDPI · 2023Article
- Understanding the evolution of immune genes in jawed vertebrates.Journal of evolutionary biology · 2023Review
- Recovered frog populations coexist with endemic Batrachochytrium dendrobatidis despite load-dependent mortality.Ecological applications : a publication of the Ecological Society of America · 2023Article
- Habitat fragmentation in the Brazilian Atlantic Forest is associated with erosion of frog immunogenetic diversity and increased fungal infections.Immunogenetics · 2022Article
- Transcriptome annotation reveals minimal immunogenetic diversity among Wyoming toads,Conservation genetics (Print) · 2022Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathogenic chytrid fungus Batrachochytrium dendrobatidis (Bd) can cause precipitous population declines in its amphibian hosts. Responses of individuals to infection vary greatly with the capacity of their immune system to respond to the pathogen. We used a combination of comparative and experimental approaches to identify major histocompatibility complex class II (MHC-II) alleles encoding molecules that foster the survival of Bd-infected amphibians. We found that Bd-resistant amphibians across four continents share common amino acids in three binding pockets of the MHC-II antigen-binding groove. Moreover, strong signals of selection acting on these specific sites were evident among all species co-existing with the pathogen. In the laboratory, we experimentally inoculated Australian tree frogs with Bd to test how each binding pocket conformation influences disease resistance. Only the conformation of MHC-II pocket 9 of surviving subjects matched those of Bd-resistant species. This MHC-II conformation thus may determine amphibian resistance to Bd, although other MHC-II binding pockets also may contribute to resistance. Rescuing amphibian biodiversity will depend on our understanding of amphibian immune defence mechanisms against Bd. The identification of adaptive genetic markers for Bd resistance represents an important step forward towards that goal.
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