Evidence map›Paper›PMID 25808802›Full record

ArticleJournal of neurotrauma2016

Predicting Outcome after Pediatric Traumatic Brain Injury by Early Magnetic Resonance Imaging Lesion Location and Volume.

Emily Smitherman, Ana Hernandez, Peter L Stavinoha, Rong Huang, Steven G Kernie, Ramon Diaz-Arrastia, Darryl K Miles

Abstract read
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In one paragraph

Article in Journal of neurotrauma, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  20. Local and global challenges in pediatric traumatic brain injury outcome and rehabilitation assessment.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emily Smitherman1 University of Texas Southwestern Medical Center, University of Texas Southwestern Medical Center , Dallas, Texas.
Ana Hernandez2 Department of Neuropsychology, Children's Medical Center , Dallas, Texas.
Peter L Stavinoha2 Department of Neuropsychology, Children's Medical Center , Dallas, Texas.
Rong Huang4 Department of Clinical Research, Children's Medical Center , Dallas, Texas.
Steven G Kernie5 Department of Pediatrics, University of Texas Southwestern Medical Center , Dallas, Texas.
Ramon Diaz-Arrastia6 Department of Neurology, University of Texas Southwestern Medical Center , Dallas, Texas.
Darryl K Miles5 Department of Pediatrics, University of Texas Southwestern Medical Center , Dallas, Texas.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain lesions after traumatic brain injury (TBI) are heterogeneous, rendering outcome prognostication difficult. The aim of this study is to investigate whether early magnetic resonance imaging (MRI) of lesion location and lesion volume within discrete brain anatomical zones can accurately predict long-term neurological outcome in children post-TBI. Fluid-attenuated inversion recovery (FLAIR) MRI hyperintense lesions in 63 children obtained 6.2±5.6 days postinjury were correlated with the Glasgow Outcome Scale Extended-Pediatrics (GOS-E Peds) score at 13.5±8.6 months. FLAIR lesion volume was expressed as hyperintensity lesion volume index (HLVI)=(hyperintensity lesion volume / whole brain volume)×100 measured within three brain zones: zone A (cortical structures); zone B (basal ganglia, corpus callosum, internal capsule, and thalamus); and zone C (brainstem). HLVI-total and HLVI-zone C predicted good and poor outcome groups (p<0.05). GOS-E Peds correlated with HLVI-total (r=0.39; p=0.002) and HLVI in all three zones: zone A (r=0.31; p<0.02); zone B (r=0.35; p=0.004); and zone C (r=0.37; p=0.003). In adolescents ages 13-17 years, HLVI-total correlated best with outcome (r=0.5; p=0.007), whereas in younger children under the age of 13, HLVI-zone B correlated best (r=0.52; p=0.001). Compared to patients with lesions in zone A alone or in zones A and B, patients with lesions in all three zones had a significantly higher odds ratio (4.38; 95% confidence interval, 1.19-16.0) for developing an unfavorable outcome.

Indexed as

Outcome Assessment, Health CareAdolescentAge FactorsBasal GangliaBiomarkersBrain InjuriesBrain StemCerebral CortexChildChild, PreschoolCorpus CallosumFemaleGlasgow Outcome ScaleHumansInfantInternal CapsuleBiomarkersbiomarkerscognitive functionMRIoutcome measurespediatric brain injury

Identifiers

PMID25808802
PMCPMC4700399

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.