ArticleEuropean journal of nuclear medicine and molecular imaging2015
First experience of simultaneous PET/MRI for the early detection of cardiac involvement in patients with Anderson-Fabry disease.
Article in European journal of nuclear medicine and molecular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03199001 (Native T1 Mapping by Cardiovascular Magnetic Resonance Imaging in Rare Diseases- A New Method to Improve Patient Care), which is not on this map. Cited by 46 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Native T1 Mapping by Cardiovascular Magnetic Resonance Imaging in Rare Diseases- A New Method to Improve Patient Care
Who cites it
46 citing papers in PubMed, 76 citations in OpenAlex.
- Cardiological aspects of Fabry disease: from diagnosis to therapeutic efficacy assessment.Orphanet journal of rare diseases · 2026Review
- Review
- Contemporary Multimodality Imaging for Diagnosis and Management of Fabry Cardiomyopathy.Journal of clinical medicine · 2024Review
- Inflammation, Oxidative Stress, and Endothelial Dysfunction in the Pathogenesis of Vascular Damage: Unraveling Novel Cardiovascular Risk Factors in Fabry Disease.International journal of molecular sciences · 2024Review
- Arrhythmogenesis in Fabry Disease.Current cardiology reports · 2024Review
- Detection of sympathetic denervation defects in Fabry disease by hybrid [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Impairment of sympathetic activity in Fabry disease cardiomyopathy: A further challenge for cardiac imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Advanced CMR Techniques in Anderson-Fabry Disease: State of the Art.Diagnostics (Basel, Switzerland) · 2023Review
- Positron Emission Tomography in Heart Failure: From Pathophysiology to Clinical Application.Journal of cardiovascular development and disease · 2023Review
- Left Ventricular Apical Aneurysm in Fabry Disease: Implications for Clinical Significance and Risk Stratification.Journal of the American Heart Association · 2023Article
- Multimodality imaging approach to Fabry cardiomyopathy: Any role for nuclear cardiology?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Review
- Fabry Disease Cardiomyopathy: A Review of the Role of Cardiac Imaging from Diagnosis to Treatment.Reviews in cardiovascular medicine · 2022Review
- Cardiac Magnetic Resonance Features of Fabry Disease: From Early Diagnosis to Prognostic Stratification.Reviews in cardiovascular medicine · 2022Review
- Multimodality Cardiac Imaging in Cardiomyopathies: From Diagnosis to Prognosis.Journal of clinical medicine · 2022Review
- Various Aspects of Fasting on the Biodistribution of Radiopharmaceuticals.Current drug metabolism · 2022Review
- New insights for early assessment of cardiac involvement in Anderson-Fabry disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Cardiac hybrid imaging: novel tracers for novel targets.Journal of geriatric cardiology : JGC · 2021Article
- Role of serial cardiacInsights into imaging · 2021Article
- Current status of cardiac manifestations in Fabry disease and their treatment.Medicine and pharmacy reports · 2021Article
- Cardiac Imaging in Anderson-Fabry Disease: Past, Present and Future.Journal of clinical medicine · 2021Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAnderson-Fabry disease (AFD) is an X-linked lysosomal storage disorder associated with severe multiorgan dysfunction and premature death. Early diagnosis and treatment strategies play a key role in patient outcome. We investigated the potential role of hybrid PET/MR imaging in the assessment of early cardiac involvement in AFD patients.
methodsThirteen AFD patients without cardiac symptoms and with normal left ventricular function underwent simultaneous cardiac PET/MR imaging after administration of (18)F-FDG. Cardiac FDG uptake was quantified by measuring the standardized uptake value in 17 myocardial segments in each subject. The coefficient of variation (COV, i.e. the standard deviation divided by the average) of the uptake of the 17 segments was calculated as an index of heterogeneity in the heart.
resultsSix patients exhibited focal late gadolinium enhancement (LGE) indicating intramyocardial fibrosis, and four of these also had positive short inversion time inversion recovery (STIR) sequences. All patients with LGE and positive STIR MR images showed focal FDG uptake in the corresponding myocardial segments indicating inflammation. Of the seven patients with negative LGE and STIR images, five showed homogeneous FDG cardiac uptake and two showed heterogeneous FDG uptake. The COV was significantly greater in patients with focal FDG uptake (0.25 ± 0.02) than in those without (0.14 ± 0.07, p < 0.01).
conclusionPET/MR imaging is clinically feasible for the early detection of cardiac involvement in patients with AFD. Further studies evaluating the role of hybrid PET/MR imaging in management of the disease in larger patient populations are warranted.
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