ArticleBiology2015
Body-Mass Scaling of Metabolic Rate: What are the Relative Roles of Cellular versus Systemic Effects?
Article in Biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Non-lethal imaging and modeling approaches for estimating dry mass in aquatic larvae.PloS one · 2026Article
- Associations between metabolic rate and personality in a free-living small mammal are driven by date of birth.Royal Society open science · 2025Article
- Establishment of cell size-dependent growth rate via differential scaling of metabolite uptake and release.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Development of a novel high-throughput culture system for hypoxic 3D hydrogel cell culture.Scientific reports · 2024Article
- The incubation environment does not explain significant variation in heart rate plasticity among avian embryos.The Journal of experimental biology · 2024Article
- A sense of proximity: Cell packing modulates oxygen consumption.APL bioengineering · 2023Article
- Article
- Metabolic regulation of endothelial senescence.Frontiers in cardiovascular medicine · 2023Review
- Variable metabolic scaling breaks the law: from 'Newtonian' to 'Darwinian' approaches.Proceedings. Biological sciences · 2022Article
- White Paper: An Integrated Perspective on the Causes of Hypometric Metabolic Scaling in Animals.Integrative and comparative biology · 2022Article
- How Metabolic Rate Relates to Cell Size.Biology · 2022Review
- Scaling of joint mass and metabolism fluctuations in in silico cell-laden spheroids.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Activity alters how temperature influences intraspecific metabolic scaling: testing the metabolic-level boundaries hypothesis.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Effects of Fish Predators on the Mass-Related Energetics of a Keystone Freshwater Crustacean.Biology · 2020Article
- Oxygen Consumption Characteristics in 3D Constructs Depend on Cell Density.Frontiers in bioengineering and biotechnology · 2019Article
- 'Extreme' organisms and the problem of generalization: interpreting the Krogh principle.History and philosophy of the life sciences · 2018Article
- Allometric scaling in-vitro.Scientific reports · 2017Article
- The bioenergetic costs of a gene.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The reason why metabolic rate often scales allometrically (disproportionately) with body mass has been debated for decades. A critical question concerns whether metabolic scaling is controlled intrinsically at the intracellular level or systemically at the organismal level. Recently, the relative importance of these effects has been tested by examining the metabolic rates of cultured dermal fibroblast and skeletal muscle cells in relation to donor body mass of a variety of birds and mammals. The lack of a relationship between in vitro cellular metabolic rates and body mass suggests that systemic effects, not intrinsic cellular effects are responsible for allometric metabolic scaling observed in whole organisms. Influential resource-transport network theory claims that the most important systemic effect involved is body-size related resource-supply limits to metabolizing cells. However, comparisons of in vitro cellular metabolic rates with scaling relationships for in vivo (basal) metabolic rates suggest that other systemic effects, such as body-size dependent biological regulation and tissue composition may also have major, perhaps more important effects. Furthermore, systemic effects must ultimately act at the cellular level, for example, by induced variation in the function, structure and intracellular densities of mitochondria. The mechanistic pathways involved require further study.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.