ReviewWiley interdisciplinary reviews. Systems biology and medicine
Integrative models of vascular remodeling during tumor growth.
Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 81 citations in OpenAlex.
- Article
- Computational modeling and simulation in oncology.Clinical and translational medicine · 2025Article
- Hypoxia Imaging in Lung Cancer: A PET-Based Narrative Review for Clinicians and Researchers.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Denoising strategies of functional connectivity MRI data in lesional and non-lesional brain diseases.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment.Biology direct · 2023Article
- A Simulation of the Effects of Diffusion on Hyperpolarized [1-IEEE transactions on bio-medical engineering · 2023Article
- Approaches to vascular network, blood flow, and metabolite distribution modeling in brain tissue.Biophysical reviews · 2023Review
- Computational models for generating microvascular structures: Investigations beyond medical imaging resolution.WIREs mechanisms of disease · 2023Review
- A proof-of-concept pipeline to guide evaluation of tumor tissue perfusion by dynamic contrast-agent imaging: Direct simulation and inverse tracer-kinetic procedures.Frontiers in bioinformatics · 2023Article
- Clinical Trials for Oral, Inhaled and Intravenous Drug Delivery System for Lung Cancer and Emerging Nanomedicine-Based Approaches.International journal of nanomedicine · 2023Review
- Mechanobiology in oncology: basic concepts and clinical prospects.Frontiers in cell and developmental biology · 2023Review
- Systems biology of angiogenesis signaling: Computational models and omics.WIREs mechanisms of disease · 2022Review
- An Updated Review on EPR-Based Solid Tumor Targeting Nanocarriers for Cancer Treatment.Cancers · 2022Review
- A Fokker-Planck feedback control framework for optimal personalized therapies in colon cancer-induced angiogenesis.Journal of mathematical biology · 2022Article
- LINC01615 activates ZEB2 through competitively binding with miR-3653-3p to promote the carcinogenesis of colon cancer cells.Cell cycle (Georgetown, Tex.) · 2022Article
- Crosstalk between HER2 and PD-1/PD-L1 in Breast Cancer: From Clinical Applications to Mathematical Models.Cancers · 2020Review
- Necrosis in the Tumor Microenvironment and Its Role in Cancer Recurrence.Advances in experimental medicine and biology · 2020Review
- Glioblastoma multiforme restructures the topological connectivity of cerebrovascular networks.Scientific reports · 2019Article
- Fine-grained simulations of the microenvironment of vascularized tumours.Scientific reports · 2019Article
- Modelling the transport of fluid through heterogeneous, whole tumours in silico.PLoS computational biology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledMalignant solid tumors recruit the blood vessel network of the host tissue for nutrient supply, continuous growth, and gain of metastatic potential. Angiogenesis (the formation of new blood vessels), vessel cooption (the integration of existing blood vessels into the tumor vasculature), and vessel regression remodel the healthy vascular network into a tumor-specific vasculature that is in many respects different from the hierarchically organized arterio-venous blood vessel network of the host tissues. Integrative models based on detailed experimental data and physical laws implement in silico the complex interplay of molecular pathways, cell proliferation, migration, and death, tissue microenvironment, mechanical and hydrodynamic forces, and the fine structure of the host tissue vasculature. With the help of computer simulations high-precision information about blood flow patterns, interstitial fluid flow, drug distribution, oxygen and nutrient distribution can be obtained and a plethora of therapeutic protocols can be tested before clinical trials. In this review, we give an overview over the current status of integrative models describing tumor growth, vascular remodeling, blood and interstitial fluid flow, drug delivery, and concomitant transformations of the microenvironment. WIREs Syst Biol Med 2015, 7:113-129. doi: 10.1002/wsbm.1295 For further resources related to this article, please visit the WIREs website. CONFLICT OF INTEREST: The authors have declared no conflicts of interest for this article.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.