ArticleThe Journal of cell biology1985
Gliding movement of and bidirectional transport along single native microtubules from squid axoplasm: evidence for an active role of microtubules in cytoplasmic transport.
Article in The Journal of cell biology, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
88 citing papers in PubMed, 440 citations in OpenAlex.
- Methods to Measure Water Permeability.Advances in experimental medicine and biology · 2023Article
- Kv7 channel trafficking by the microtubule network in vascular smooth muscle.Acta physiologica (Oxford, England) · 2021Review
- Membrane mediated motor kinetics in microtubule gliding assays.Scientific reports · 2019Article
- Harnessing Motile Amoeboid Cells as Trucks for Microtransport and -Assembly.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Evolution of research on cellular motility over five decades.Biophysical reviews · 2018Review
- A stochastic model that explains axonal organelle pileups induced by a reduction of molecular motors.Journal of the Royal Society, Interface · 2018Article
- Spontaneous oscillations of elastic filaments induced by molecular motors.Journal of the Royal Society, Interface · 2017Article
- Highly potent intracellular membrane-associated Aβ seeds.Scientific reports · 2016Article
- Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease.The Journal of biological chemistry · 2016Article
- Dividing organelle tracks into Brownian and motor-driven intervals by variational maximization of the Bayesian evidence.European biophysics journal : EBJ · 2016Article
- What Renders TAU Toxic.Frontiers in neurology · 2013Article
- A numbers game underpins cytoplasmic mRNA transport.Nature cell biology · 2012Article
- Cytoskeletal signaling: is memory encoded in microtubule lattices by CaMKII phosphorylation?PLoS computational biology · 2012Article
- Simulation of cyclic dynein-driven sliding, splitting, and reassociation in an outer doublet pair.Biophysical journal · 2009Article
- No conventional function for the conventional kinesin?Traffic (Copenhagen, Denmark) · 2008Article
- The alpha-helix, an overlooked molecular motor.Protoplasma · 2005Review
- Immunohistochemical characterisation of differentiated CAD cells: expression of peptides and chromogranins.Histochemistry and cell biology · 2005Article
- Myosin Va bound to phagosomes binds to F-actin and delays microtubule-dependent motility.Molecular biology of the cell · 2001Article
- Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport.Molecular biology of the cell · 1999Article
- Prostaglandins protect human intestinal cells against ethanol injury by stabilizing microtubules: role of protein kinase C and enhanced calcium efflux.Digestive diseases and sciences · 1999Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Native microtubules prepared from extruded and dissociated axoplasm have been observed to transport organelles and vesicles unidirectionally in fresh preparations and more slowly and bidirectionally in older preparations. Both endogenous and exogenous (fluorescent polystyrene) particles in rapid Brownian motion alight on and adhere to microtubules and are transported along them. Particles can switch from one intersecting microtubule to another and move in either direction. Microtubular segments 1 to 30 microns long, produced by gentle homogenization, glide over glass surfaces for hundreds of micrometers in straight lines unless acted upon by obstacles. While gliding they transport particles either in the same (forward) direction and/or in the backward direction. Particle movement and gliding of microtubule segments require ATP and are insensitive to taxol (30 microM). It appears, therefore, that the mechanisms producing the motive force are very closely associated with the native microtubule itself or with its associated proteins. Although these movements appear irreconcilable with several current theories of fast axoplasmic transport, in this article we propose two models that might explain the observed phenomena and, by extension, the process of fast axoplasmic transport itself. The findings presented and the possible mechanisms proposed for fast axoplasmic transport have potential applications across the spectrum of microtubule-based motility processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.