Evidence map›Paper›PMID 25808343›Full record

ArticleJournal of the Royal Society, Interface2015

Hierarchical analysis and multi-scale modelling of rat cortical and trabecular bone.

Ramin Oftadeh, Vahid Entezari, Guy Spörri, Juan C Villa-Camacho, Henry Krigbaum, Elsa Strawich, Lila Graham, Christian Rey, Hank Chiu, Ralph Müller and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Royal Society, Interface, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ramin OftadehCenter for Advanced Orthopaedic Studies, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA, USA.
Vahid EntezariCenter for Advanced Orthopaedic Studies, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Guy SpörriCenter for Advanced Orthopaedic Studies, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA Institute for Biomechanics, ETH Zurich, Zurich, Switzerland.
Juan C Villa-CamachoCenter for Advanced Orthopaedic Studies, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Henry KrigbaumDepartment of Orthopaedics, University of California, San Francisco, CA, USA.
Elsa StrawichLaboratory for the Study of Skeletal Disorders and Rehabilitation, Boston Children's Hospital, Department of Orthopaedic Surgery, Harvard Medical School, Boston, MA, USA.
Lila GrahamLaboratory for the Study of Skeletal Disorders and Rehabilitation, Boston Children's Hospital, Department of Orthopaedic Surgery, Harvard Medical School, Boston, MA, USA.
Christian ReyCentre Inter Universitaire de Recherche et d'Ingénierie des Matériaux, Ecole Nationale Supérieure des Ingénieurs en Arts Chimiques et Technologiques, Toulouse, France.
Hank ChiuDepartment of Biomedical Engineering, University of Memphis, Memphis, TN, USA.
Ralph MüllerInstitute for Biomechanics, ETH Zurich, Zurich, Switzerland.
Hamid Nayeb HashemiDepartment of Mechanical and Industrial Engineering, Northeastern University, Boston, MA, USA.
Ashkan VaziriDepartment of Mechanical and Industrial Engineering, Northeastern University, Boston, MA, USA.
Ara NazarianCenter for Advanced Orthopaedic Studies, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA anazaria@bidmc.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to explore the hierarchical arrangement of structural properties in cortical and trabecular bone and to determine a mathematical model that accurately predicts the tissue's mechanical properties as a function of these indices. By using a variety of analytical techniques, we were able to characterize the structural and compositional properties of cortical and trabecular bones, as well as to determine the suitable mathematical model to predict the tissue's mechanical properties using a continuum micromechanics approach. Our hierarchical analysis demonstrated that the differences between cortical and trabecular bone reside mainly at the micro- and ultrastructural levels. By gaining a better appreciation of the similarities and differences between the two bone types, we would be able to provide a better assessment and understanding of their individual roles, as well as their contribution to bone health overall.

Indexed as

Models, BiologicalAnimalsBone DensityCompressive StrengthComputer SimulationElastic ModulusFemaleFemurHardnessModels, AnatomicRatsRats, Sprague-DawleyStress, MechanicalTensile Strengthbone composition and structurebone mechanical propertiescontinuum micromechanicscortical and trabecular bonehierarchical analysis

Identifiers

PMID25808343
PMCPMC4424685

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.