ReviewNutrients2015
The controversial role of food allergy in infantile colic: evidence and clinical management.
Review in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Trial
- Associations of Colic and Excessive Crying in Infancy with Food Allergy Outcomes in Childhood and Adolescence.The Journal of pediatrics · 2026Article
- Infantile Colic: When to Suspect Cow's Milk Allergy.Nutrients · 2025Review
- Infant Colic Symptoms and Amino Acid Formula: Insights from a Prospective Cohort Study.Nutrients · 2025Article
- Uncovering the Effects of Different Formulae of Milk Powders on the Fecal Microorganisms and Metabolites of Bengal Tiger (Animals : an open access journal from MDPI · 2025Article
- Infantile colic is associated with development of later constipation and atopic disorders.Allergy · 2024Article
- [Interpretation of key points from the "Expert Consensus on Diagnosis and Management of Neonatal Cow Milk Protein Allergy (2023)"].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Hydrolysed Formulas in the Management of Cow's Milk Allergy: New Insights, Pitfalls and Tips.Nutrients · 2021Review
- Cow's Milk Allergy or Gastroesophageal Reflux Disease-Can We Solve the Dilemma in Infants?Nutrients · 2021Review
- Clinical Evidence of Vestibular Dysregulation in Colicky Babies Before and After Chiropractic Treatment vs. Non-colicky Babies.Frontiers in pediatrics · 2021Article
- An Electrochemical Sensor Based on Gold-Nanocluster-Modified Graphene Screen-Printed Electrodes for the Detection of β-Lactoglobulin in Milk.Sensors (Basel, Switzerland) · 2020Article
- Review
- A free amino acid-based diet partially prevents symptoms of cow's milk allergy in mice after oral sensitization with whey.Immunity, inflammation and disease · 2020Article
- Functional Gastrointestinal Disorders in Infancy: Impact on the Health of the Infant and Family.Pediatric gastroenterology, hepatology & nutrition · 2019Review
- Infantile colic.Australian prescriber · 2018Review
- Acupuncture for Infantile Colic: A Systematic Review of Randomised Controlled Trials.Evidence-based complementary and alternative medicine : eCAM · 2018Review
- Knowledge, attitudes, and practices of pediatricians on infantile colic in the Middle East and North Africa region.BMC pediatrics · 2017Article
- Pain-relieving agents for infantile colic.The Cochrane database of systematic reviews · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Food allergies (FAs) are an increasing problem in Western countries, affecting up to 10% of young children. FAs are frequently associated with gastrointestinal manifestations. The role of FAs as a potential causative factor for infantile colic (IC) is still controversial. We report the most recent evidence on the pathogenesis, clinical and diagnostic aspects of FA-induced infantile colic (IC) and suggest a stepwise diagnostic approach. We selected articles on clinical and immunologic features, pathogenesis and management of FAs and IC from of 1981 to 2015. Original and review articles were identified through selective searches performed on PubMed, using the following terms: colic, infantile colic, food allergy and infantile colic, infantile colic treatment. The possible relationship between FAs and IC derives from the presence of dysmotility with visceral hypersensitivity and dysbiosis, demonstrated in both conditions, and the clinical response to dietary interventions. Unfortunately, the design of the studies, poor characterization of atopy and different dietary approaches limit the understanding of the importance of FAs in subjects with IC. The role of FAs in IC subjects without other symptoms of atopy remains controversial. However, where there is a suspicion of FAs, a short trial with an extensively hydrolyzed cow's proteins formula or, if breast fed, with maternal elimination diet may be considered a reasonable option.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.