ArticleProtein science : a publication of the Protein Society2015
Arginine: Its pKa value revisited.
Article in Protein science : a publication of the Protein Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers.
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Who cites it
153 citing papers in PubMed.
- Effect of arginine-fluoride varnish on preventing enamel erosion by paediatric liquid medicaments.BMC oral health · 2023Trial
- L-Arginine inhibits NLRP3 inflammasome activation.Nature metabolism · 2026Article
- Intraprocedural Hemodynamics During Concomitant Rheocarna Therapy and Maintenance Hemodialysis: Effects of Dialyzer Membrane Type and Circuit Sequence.Journal of clinical apheresis · 2026Article
- Predicting pH-Dependent Solubility Enhancement and Precipitation Suppression in Drug-Cyclodextrin-Arginine Formulations.Pharmaceutics · 2026Article
- Bio-Inspired, Zwitterionic Copolymers with Amphiphilic Character.Macromolecular rapid communications · 2026Article
- Modulation of Intravenous Immunoglobulin Aggregation, Subvisible Particle Formation, and Viscosity by Acetylated Amino Acids.Pharmaceutics · 2026Article
- L-Arginine-Modified Chitosan Curcumin Nanocrystals Target M1 Macrophages via CAT-2/Clathrin-Mediated Endocytosis for Mitochondrial Protection and ALI/ARDS Therapy.Pharmaceutics · 2026Article
- Dual Amino Acid Swap in MUC7-Derived Peptide Enhances Resistance and Modulates Zn(II) and Cu(II) Complex Stability, Secondary Structure and Antimicrobial Activity.Inorganic chemistry · 2026Article
- Utilizing L-arginine as an eco-friendly absorbent for hydrogen sulfide mitigation in produced water.Scientific reports · 2026Article
- Article
- Water Molecule(s) Inside the Selectivity Filter of Aquaporin 1: A DFT Study.Molecules (Basel, Switzerland) · 2026Article
- Lung-targeted RNA delivery systems: strategies and therapeutic applications.Journal of nanobiotechnology · 2026Review
- HomozygousFrontiers in cardiovascular medicine · 2026Article
- Unravelling Catalytic Divergence in Mo- and Fe-Only Nitrogenases: The Role of the Heterometal-Site and Protein Environment from QM/MM Insights.Journal of the American Chemical Society · 2025Article
- The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin.Science (New York, N.Y.) · 2025Article
- Indel-driven evolution of the canavanine tRNA-editing deacetylase enzyme CtdA.Journal of structural biology: X · 2025Article
- Nonspecific Binding of a Putative S-Layer Protein to Plant Cell Wall Polysaccharides-Implication for Growth Competence ofInternational journal of molecular sciences · 2025Article
- Expanding Peptide Chemical Space via Acid-Mediated Arginine Modification.Organic letters · 2025Article
- Cationic Peptoids for Systemic In Vivo Cartilage-Targeting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Charge Neutralization During Peptide Transport in the Bacterial SecYEG Translocon.Biomolecules · 2025Article
93 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Using complementary approaches of potentiometry and NMR spectroscopy, we have determined that the equilibrium acid dissociation constant (pKa value) of the arginine guanidinium group is 13.8 ± 0.1. This is substantially higher than that of ∼ 12 often used in structure-based electrostatics calculations and cited in biochemistry textbooks. The revised intrinsic pKa value helps explains why arginine side chains in proteins are always predominantly charged, even at pH values as great as 10. The high pKa value also reinforces the observation that arginine side chains are invariably protonated under physiological conditions of near neutral pH. This occurs even when the guanidinium moiety is buried in a hydrophobic micro-environment, such as that inside a protein or a lipid membrane, thought to be incompatible with the presence of a charged group.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.