Trial reportThe American journal on addictions2015
D-cycloserine combined with cue exposure therapy fails to attenuate subjective and physiological craving in cocaine dependence.
Trial report in The American journal on addictions, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Efficacy and mechanisms of repeated closed-loop auditory exposure during slow-wave sleep for internet gaming disorder.Molecular psychiatry · 2025Trial
- A randomized, placebo-controlled laboratory study of the effects of D-cycloserine on sexual memory consolidation in women.Psychopharmacology · 2020Trial
- Randomized controlled trial of d-cycloserine in cocaine dependence: Effects on contingency management and cue-induced cocaine craving in a naturalistic setting.Experimental and clinical psychopharmacology · 2020Trial
- The relationship between years of cocaine use and brain activation to cocaine and response inhibition cues.Addiction (Abingdon, England) · 2014Trial
- Impact of DCS-facilitated cue exposure therapy on brain activation to cocaine cues in cocaine dependence.Drug and alcohol dependence · 2013Trial
- Prospective associations between brain activation to cocaine and no-go cues and cocaine relapse.Drug and alcohol dependence · 2013Trial
- Crosstalk Between Glycinergic and N-Methyl-D-Aspartate Receptor-Mediated Glutamatergic Transmission in Behaviours Associated with Opioid Use Disorder.International journal of molecular sciences · 2025Review
- Cocaine Cues Used in Experimental Research: A Systematic Review.Brain sciences · 2025Review
- Transforming experiences: Neurobiology of memory updating/editing.Frontiers in systems neuroscience · 2023Review
- A transdiagnostic meta-analysis of acute augmentations to psychological therapy.Nature. Mental health · 2023Article
- Pharmacological Treatments for Cocaine Craving: What Is the Way Forward? A Systematic Review.Brain sciences · 2022Review
- Extinction vs. Abstinence: A Review of the Molecular and Circuit Consequences of Different Post-Cocaine Experiences.International journal of molecular sciences · 2021Review
- Molecular and circuit mechanisms regulating cocaine memory.Cellular and molecular life sciences : CMLS · 2020Review
- Sex differences in the effects of a combined behavioral and pharmacological treatment strategy for cocaine relapse prevention in an animal model of cue exposure therapy.Behavioural brain research · 2020Article
- Facilitative effects of environmental enrichment for cocaine relapse prevention are dependent on extinction training context and involve increased TrkB signaling in dorsal hippocampus and ventromedial prefrontal cortex.Behavioural brain research · 2020Article
- The effects of Pavlovian cue extinction and ceftriaxone on cocaine relapse after abstinence.Drug and alcohol dependence · 2019Article
- Cocaine-induced Changes in the Expression of NMDA Receptor Subunits.Current neuropharmacology · 2019Review
- Effects of muscarinic MPsychopharmacology · 2018Article
- Environmental enrichment facilitates cocaine-cue extinction, deters reacquisition of cocaine self-administration and alters AMPAR GluA1 expression and phosphorylation.Addiction biology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBased on preclinical studies showing that the partial N-methyl-D-aspartate (NMDA) agonist D-cycloserine (DCS) facilitates extinction of cocaine self-administration and cocaine-induced conditioned place preference, we evaluated whether 50 mg of DCS would reduce craving to cocaine cues when combined with cue exposure (CE) in cocaine dependent humans.
methodsIn this double-blind placebo-controlled pilot study, 47 cocaine dependent participants were randomized to DCS or placebo (PBO), plus CE. Participants received DCS or PBO 30 minutes prior to two CE sessions, conducted one day apart. Craving and heart rate was assessed prior to CE sessions, during CE trials, and after CE trials. These measures were assessed again at a 1-week follow-up (session 3) after the second CE session.
resultsDCS failed to significantly attenuate cocaine cue reactivity based on subjective craving and physiological reactivity (heart rate) compared to PBO. The CE protocol, consisting of repeated exposure to drug cues combined with skills training, resulted in extinction to cocaine cues as suggested by decreased craving within and between sessions in both treatment conditions. All participants exhibited elevated heart rate with repeated exposures, demonstrating a potentiation in heart rate between sessions.
conclusions50 mg of DCS may not be effective for extinguishing reactivity to drug cues for individuals with cocaine dependence. SCIENTIFIC SIGNIFICANCE: Future studies examining the effect of DCS on facilitating extinction to drug cues should examine variations in cue exposure length, number of CE presentations, and timing of DCS dose administration prior to cue exposures, which may differentially impact drug cue reactivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.