ReviewPaediatric and perinatal epidemiology2015
Early pregnancy maternal vitamin D concentrations and risk of gestational diabetes mellitus.
Review in Paediatric and perinatal epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Circulating vitamin D and the risk of gestational diabetes: a systematic review and dose-response meta-analysis.Endocrine · 2020Pooled it
- Vitamin D Deficiency Increases the Risk of Gestational Diabetes Mellitus: A Meta-Analysis of Observational Studies.Nutrients · 2015Pooled it
- Vitamin D Deficiency During Pregnancy Is Associated With Greater LDL-C Increase, Elevated β-Hydroxybutyrate and Altered Neonatal Metabolic Markers-A Secondary, Pooled Analysis of the Randomized, Controlled Vitamin D and Lifestyle for Gestational Diabetes Prevention Trial (DALI).Endocrinology, diabetes & metabolism · 2026Trial
- Associations between genetic variants of vitamin D metabolic pathway and gestational diabetes mellitus: the potential mediation role of serum 25(OH)DBMC endocrine disorders · 2026Article
- Vitamin D status during pregnancy modulates the effect of pre-pregnancy obesity on gestational diabetes mellitus risk: a birth cohort study.Public health nutrition · 2026Article
- Article
- Vitamin D Deficiency and Risk of Gestational Diabetes Mellitus in Western Countries: A Scoping Review.Nutrients · 2025Article
- "You are my sunshine, my only sunshine": maternal vitamin D status and supplementation in pregnancy and their effect on neonatal and childhood outcomes.Hormones (Athens, Greece) · 2023Review
- The role of 25(OH)D3 and circRNAs in early diagnosis of gestational diabetes mellitus.Journal of clinical laboratory analysis · 2023Article
- Particulate matter may have a limited influence on maternal vitamin D levels.Scientific reports · 2022Article
- Serum Vitamin D Concentrations, Time to Pregnancy, and Pregnancy Outcomes among Preconception Couples: A Cohort Study in Shanghai, China.Nutrients · 2022Article
- Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women.BMC pregnancy and childbirth · 2022Article
- High early pregnancy serum 25-hydroxy vitamin D level, within a sub-optimal range, is associated with gestational diabetes mellitus: a prospective cohort study.Nutrition research and practice · 2022Article
- The Impact of Nutritional Supplementation During Pregnancy on the Incidence of Gestational Diabetes and Glycaemia Control.Frontiers in nutrition · 2022Review
- The relationship between maternal vitamin D deficiency and glycolipid metabolism and adverse pregnancy outcome.Clinical endocrinology · 2020Article
- Is First Trimester Maternal 25-Hydroxyvitamin D Level Related to Adverse Maternal and Neonatal Pregnancy Outcomes? A Prospective Cohort Study among Malaysian Women.International journal of environmental research and public health · 2020Article
- Perinatal urinary benzophenone-3 concentrations and glucose levels among women from a fertility clinic.Environmental health : a global access science source · 2020Article
- Assessing a method and reference material for quantification of vitamin D binding protein during pregnancy.Clinical mass spectrometry (Del Mar, Calif.) · 2020Article
- Prevalence and risk factors of gestational diabetes mellitus among pregnant patients visiting National Guard primary health care centers in Saudi Arabia.Saudi medical journal · 2020Article
- Serum vitamin D deficiency and risk of gestational diabetes mellitus: a meta-analysis.Archives of medical science : AMS · 2020Review
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7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWhile associations of vitamin D deficiency with type 2 diabetes have been well demonstrated, investigations of vitamin D and risk of gestational diabetes mellitus (GDM) reported inconsistent findings. We examined associations of vitamin D status with GDM.
methodsIn a nested case-cohort study (135 GDM cases and 517 non-GDM controls), we measured maternal serum vitamin D status (total 25[OH]D and 25[OH]D3 ) in early pregnancy (16 weeks on average) using liquid chromatography-tandem mass spectroscopy. GDM was diagnosed according to the American Diabetes Association guidelines. We calculated adjusted odds ratios and 95% confidence intervals (CIs) using logistic regression models.
resultsGDM cases had lower mean total 25[OH]D (27.3 vs. 29.3 ng/mL) and 25[OH]D3 (23.9 vs. 26.7 ng/mL) concentrations compared with women who did not develop GDM (both P-values < 0.05). Overall, 25[OH]D3 concentrations, but not total 25[OH]D concentrations, were significantly associated with GDM risk. A 5-ng/mL increase in 25[OH]D3 concentration was associated with a 14% decrease in GDM risk (P-value = 0.02). Women in the lowest quartile for 25[OH]D3 concentration had a twofold [95% CI 1.15, 3.58] higher risk of GDM compared with women in the highest quartile (P-value for trend < 0.05).
conclusionsEarly pregnancy vitamin D status, particularly 25[OH]D3 , is inversely associated with GDM risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.