ArticleThe American journal on addictions2015
Health-related quality of life among prescription opioid-dependent patients: Results from a multi-site study.
Article in The American journal on addictions, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Health harms of non-medical prescription opioid use: A systematic review.Drug and alcohol review · 2022Pooled it
- Treatment-seeking behaviour among people with opioid use disorder in the high-income countries: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Opioid consumption frequency and its associations with potential life problems during opioid agonist treatment in individuals with prescription-type opioid use disorder: exploratory results from the OPTIMA Study.Harm reduction journal · 2025Trial
- Determinants of health-related quality of life among individuals with opioid use disorder, recently released from incarceration.Addiction science & clinical practice · 2023Trial
- Patient-centered Outcomes in Participants of a Buprenorphine Monthly Depot (BUP-XR) Double-blind, Placebo-controlled, Multicenter, Phase 3 Study.Journal of addiction medicineTrial
- Cognition and Depression in American Indian Elders with Prescribed Opioid Use: Data from the Strong Heart Study.Journal of racial and ethnic health disparities · 2026Article
- Quality of life measures in treatment for active substance misuse: a scoping review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Elevated rate of suicide risk in individuals with opioid use disorder.The American journal on addictions · 2025Article
- Post-discharge opioid utilization patterns in orthopedic patients are underestimated: an explorative study.Pain management · 2025Article
- Benefits ofInternational journal of molecular sciences · 2025Article
- Illicit Prescription Opioid Use Among U.S. Firefighters.Fire (Basel, Switzerland) · 2025Article
- Psychosocial correlates of depression and anxiety among treatment-seeking individuals with opioid dependence: a cross-sectional study.Frontiers in psychiatry · 2025Article
- Impact of Prescription Opioid Detoxification on Quality of Life and Pain Levels.Clinics and practice · 2024Article
- Discontinuation of psychotropic medication: a synthesis of evidence across medication classes.Molecular psychiatry · 2024Review
- Health-related quality of life and recovery capital among recovery residents taking medication for opioid use disorder in Texas.Frontiers in public health · 2023Article
- Effects of 8 months of high-intensity interval training on physical fitness and health-related quality of life in substance use disorder.Frontiers in psychiatry · 2023Article
- Patient-centered quality measurement for opioid use disorder: Development of a taxonomy to address gaps in research and practice.Substance abuse · 2022Review
- Changes in pain during buprenorphine maintenance treatment among patients with opioid use disorder and chronic pain.Journal of consulting and clinical psychology · 2022Article
- Quality of Life and Opioid Use Motives: Direct and Indirect Associations with Risky Opioid Use in a Community Sample of Adults.Substance use & misuse · 2022Article
- Beneficial Effects of Opioid Rotation to Buprenorphine/Naloxone on Opioid Misuse, Craving, Mental Health, and Pain Control in Chronic Non-Cancer Pain Patients with Opioid Use Disorder.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundAlthough prescription opioid use disorder has recently increased sharply in the United States, relatively little is known about the general well-being of this population. Assessment of quality of life in patients with substance use disorders has been recommended to improve clinical care.
objectivesHealth-related quality of life was examined in prescription opioid-dependent patients at entry to a national multi-site clinical trial, to compare quality of life scores in the study sample to other populations; further, background variables associated with quality of life in the literature were examined.
methodsPrescription opioid-dependent patients (N = 653) were compared to general populations on the Medical Outcome Study Short Form-36 (SF-36) quality of life measure; and the association between patient background variables and quality of life was examined.
resultsCompared to a general population, the current sample of prescription opioid-dependent patients had worse physical (-1.7 points, p < .001) and mental quality of life (-12.3 points, p < .001) as measured by the SF-36, similar to other opioid-use disorder populations. Within our sample, women showed more impairment than men in mental quality of life (-4.3 points, p < .001); older patients scored worse on physical (-5.2 points, p < .001), but not mental, quality of life. Chronic pain was associated with poorer physical quality of life (-9.0 points, p < .001). CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: The growing focus on wellness underscores the importance of measuring quality of life in addition to substance use outcomes. Routine assessment of health-related quality of life can add an important dimension to overall evaluation of patients' treatment response.
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