ArticlePediatric nephrology (Berlin, Germany)2015
Acute kidney injury is associated with bronchopulmonary dysplasia/mortality in premature infants.
Article in Pediatric nephrology (Berlin, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05851222 (Predicting Acute Kidney Injury in Infants Exposed to Nephrotoxic Drugs), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predicting Acute Kidney Injury in Infants Exposed to Nephrotoxic Drugs: A Big Data Approach to Predict NEOnatal Acute Kidney Injury in Newborns expoSed to nephroTOxic Drugs. (NeoAKI STOP)
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- The global prevalence of acute kidney injury (AKI) in preterm neonates: an epidemiological meta-analysis.European journal of pediatrics · 2026Pooled it
- Young adults born moderately to extremely preterm have higher eGFR and cystatin C compared to young adults born at term.Pediatric nephrology (Berlin, Germany) · 2026Article
- Examining the role of biologic sex on kidney outcomes in preterm neonates: A secondary analysis of the PENUT/REPAIReD study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Neonatal kidney injury in the hyperoxia-induced bronchopulmonary dysplasia mouse models: effect on morphology and biomarkers.Pediatric research · 2026Article
- High early fluid and sodium intake as risk factors for acute kidney injury in very-low-birthweight infants.Pediatric nephrology (Berlin, Germany) · 2026Article
- Acute kidney injury in infants with necrotising enterocolitis: A case-control study.European journal of pediatrics · 2025Article
- Employing a Haemodynamic Score to Predict Acute Kidney Injury in Infants With Patent Ductus Arteriosus.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Kidney complications in children with bronchopulmonary dysplasia.Pediatric research · 2025Article
- Acute kidney injury in late-onset neonatal bacteraemia: The role of the neonatal sequential organ failure assessment tool in predicting kidney injury.BMJ paediatrics open · 2025Article
- Post-natal steroid exposure in very low birthweight neonates and associations with acute kidney injury.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Assessing the prognostic impact of KDIGO criteria on acute kidney injury in very low birth weight infants: a critical insight.Childhood kidney diseases · 2024Article
- Association of Acute Kidney Injury with Bronchopulmonary Dysplasia in Preterm Infants.Medeniyet medical journal · 2024Article
- Low incidence of acute kidney injury in VLBW infants with restrictive use of mechanical ventilation.Pediatric nephrology (Berlin, Germany) · 2024Article
- Maternal Hypertension Disorders and Neonatal Acute Kidney Injury: Results from the AWAKEN Study.American journal of perinatology · 2024Article
- Fluid assessment, fluid balance, and fluid overload in sick children: a report from the Pediatric Acute Disease Quality Initiative (ADQI) conference.Pediatric nephrology (Berlin, Germany) · 2024Article
- Perinatal risk factors for late neonatal severe acute kidney injury in very low birth weight infants: a retrospective study.Frontiers in pediatrics · 2024Article
- Acute kidney injury decreases pulmonary vascular growth and alveolarization in neonatal rat pups.Pediatric research · 2023Article
- Premature infants born <28 weeks with acute kidney injury have increased bronchopulmonary dysplasia rates.Pediatric research · 2023Article
- Prevention of Chronic Morbidities in Extremely Premature Newborns with LISA-nCPAP Respiratory Therapy and Adjuvant Perinatal Strategies.Antioxidants (Basel, Switzerland) · 2023Review
- Acute Kidney Injury in Very Low Birth Weight Infants: A Major Morbidity and Mortality Risk Factor.Children (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAcute kidney injury (AKI) impairs electrolyte balance, alters fluid homeostasis and decreases toxin excretion. More recent data suggest it also affects the physiology of distant organs.
methodsWe performed a prospective cohort study which invloved 122 premature infants [birth weight (BW) ≤1200 g and/or gestational age (GA) <31 weeks] to determine relationships between AKI and bronchopulmonary dysplasia (BPD)/mortality. Days until oxygen discontinuation was compared between those with and without AKI in survivors who received oxygen for ≥24 h.
resultsAcute kidney disease, defined by a rise in serum creatinine (SCr) of ≥0.3 mg/dl or an increase in SCr of ≥150%, occurred in 36/122 (30%) of the premature infants. Those with AKI had a 70% higher risk of oxygen requirement or of dying at 28 days of life [relative risk (RR) 1.71, 95% confidence interval (CI) 1.22-2.39; p < 0.002]. This association remained after controlling for GA, pre-eclampsia, 5 min Apgar score and percentage maximum weight change (max % weight Δ) in the first 4 days (RR 1.45, 95% CI 1.07-1.97); p < 0.02). Similar findings were noted for receipt of mechanical ventilation/death by day 28 (adjusted RR 1.53, 95% CI 1.05-2.22; p < 0.03). Those without AKI were 2.5-fold more likely to come off oxygen [hazard ratio (HR) 1.3-5; p < 0.02) than those with AKI, even when controlling for GA, pre-eclampsia, 5 min Apgar and max % weight Δ (multivariate HR 2.0, 95% CI 0.9-4.0; p < 0.06).
conclusionsIn premature infants, AKI is associated with BPD/mortality. As AKI could lead to altered lung physiology, interventions to ameliorate AKI could improve long-term BPD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.