ArticleAnnals of neurology2015
Voxel-based morphometric magnetic resonance imaging (MRI) postprocessing in MRI-negative epilepsies.
Article in Annals of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.
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Who cites it
80 citing papers in PubMed, 1 synthesis or guideline pooled it, 150 citations in OpenAlex.
- Ultra-high field magnetic resonance imaging in human epilepsy: A systematic review.NeuroImage. Clinical · 2021Pooled it
- Magnetoencephalographic source imaging improves localization of the epileptogenic zone in multimodal imaging evaluation.Epilepsia · 2026Article
- Anatomy-corrected metabolic asymmetry predicts seizure freedom after surgery in focal cortical dysplasia.European journal of nuclear medicine and molecular imaging · 2026Article
- Neuroanatomical correlates of neuropsychological dysfunction in pediatric pharmacoresistant epilepsy due to focal cortical dysplasia type II.Epilepsia open · 2026Article
- Clinical use and radiological yield of magnetic resonance fingerprinting in epilepsy.Epilepsia · 2026Article
- Local brain volume reductions in patients with non-lesional epilepsy on 7T MRI.Neuroradiology · 2026Article
- Article
- The Capabilities of Multimodal Magnetic Resonance Morphometry to Diagnose Complex Cases of Focal Cortical Dysplasia (Pilot Study).Sovremennye tekhnologii v meditsine · 2026Article
- Surfaced-based detection of focal cortical dysplasia using magnetic resonance fingerprinting and machine learning.Epilepsia · 2026Article
- Beyond mTOR: Unraveling the Complex Pathophysiology and Signaling Pathways in Focal Cortical Dysplasia.Molecular neurobiology · 2025Review
- Utility of MR fingerprinting in differentiating epileptogenic from non-epileptogenic cortical malformations.Journal of the neurological sciences · 2025Article
- Hidden inside the sulci: Utility of voxel-based morphometric analysis program in localizing precuneus epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2025Article
- The use of automated and AI-driven algorithms for the detection of hippocampal sclerosis and focal cortical dysplasia.Epilepsia · 2025Review
- Automated Whole-Brain Focal Cortical Dysplasia Detection Using MR Fingerprinting With Deep Learning.Neurology · 2025Article
- ILAE neuroimaging task force highlight: The utility of multimodal neuroimaging in diagnostic and presurgical workup of drug-resistant focal epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2025Article
- Voxel-based and surface-based cortical morphometric MRI applications for identifying the epileptogenic zone: A narrative review.Epilepsia open · 2025Review
- Potential role of MELD and MAP18 in patients with structural temporal lobe epilepsy.Neuroradiology · 2025Article
- Lateralizing Value of Artificial Intelligence-Based Segmentation Software in MRI-Negative Focal Epilepsy.Journal of epilepsy research · 2024Article
- Focal cortical dysplasia lesion segmentation using multiscale transformer.Insights into imaging · 2024Article
- Focal cortical dysplasia (type II) detection with multi-modal MRI and a deep-learning framework.Npj imaging · 2024Article
20 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
objectiveIn the presurgical workup of magnetic resonance imaging (MRI)-negative (MRI(-) or "nonlesional") pharmacoresistant focal epilepsy (PFE) patients, discovering a previously undetected lesion can drastically change the evaluation and likely improve surgical outcome. Our study utilizes a voxel-based MRI postprocessing technique, implemented in a morphometric analysis program (MAP), to facilitate detection of subtle abnormalities in a consecutive cohort of MRI(-) surgical candidates.
methodsIncluded in this retrospective study was a consecutive cohort of 150 MRI(-) surgical patients. MAP was performed on T1-weighted MRI, with comparison to a scanner-specific normal database. Review and analysis of MAP were performed blinded to patients' clinical information. The pertinence of MAP(+) areas was confirmed by surgical outcome and pathology.
resultsMAP showed a 43% positive rate, sensitivity of 0.9, and specificity of 0.67. Overall, patients with the MAP(+) region completely resected had the best seizure outcomes, followed by the MAP(-) patients, and patients who had no/partial resection of the MAP(+) region had the worst outcome (p < 0.001). Subgroup analysis revealed that visually identified subtle findings are more likely correct if also MAP(+) . False-positive rate in 52 normal controls was 2%. Surgical pathology of the resected MAP(+) areas contained mainly non-balloon-cell focal cortical dysplasia (FCD). Multiple MAP(+) regions were present in 7% of patients.
interpretationMAP can be a practical and valuable tool to: (1) guide the search for subtle MRI abnormalities and (2) confirm visually identified questionable abnormalities in patients with PFE due to suspected FCD. A MAP(+) region, when concordant with the patient's electroclinical presentation, should provide a legitimate target for surgical exploration.
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