ArticleThe journal of trauma and acute care surgery2015
Pathologic metabolism: an exploratory study of the plasma metabolome of critical injury.
Article in The journal of trauma and acute care surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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Who cites it
50 citing papers in PubMed.
- A pilot study of alternative substrates in the critically Ill subject using a ketogenic feed.Nature communications · 2023Trial
- Mortality prediction in patients with severe septic shock: a pilot study using a target metabolomics approach.Scientific reports · 2016Trial
- High-Throughput Metabolomics in Transfusion Medicine.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Bioinformatics-Guided Identification and Quantification of Biomarkers of Crotalus atrox Envenoming and Its Neutralization by Antivenom.Molecular & cellular proteomics : MCP · 2025Article
- Integrated proteomic and metabolomic profiling of lymph after trauma-induced hypercoagulopathy and antithrombotic therapy.Thrombosis journal · 2024Article
- Identification of an Intravenous Injectable NK1 Receptor Antagonist for Use in Traumatic Brain Injury.International journal of molecular sciences · 2024Article
- Breaking barriers in trauma research: A narrative review of opportunities to leverage veterinary trauma for accelerated translation to clinical solutions for pets and people.Journal of clinical and translational science · 2024Review
- Article
- Red Blood Cell Omics and Machine Learning in Transfusion Medicine: Singularity Is Near.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023Review
- Omics Markers of Red Blood Cell Transfusion in Trauma.International journal of molecular sciences · 2022Article
- Longitudinal Metabolomics and Lipidomics Analyses Reveal Alterations Associated with Envenoming byToxins · 2022Article
- Development and Validation of Indicators for Population Injury Surveillance in Hong Kong: Development and Usability Study.JMIR public health and surveillance · 2022Review
- Plasma Levels of Acyl-Carnitines and Carboxylic Acids Correlate With Cardiovascular and Kidney Function in Subjects With Sickle Cell Trait.Frontiers in physiology · 2022Article
- Integration of Metabolomic and Clinical Data Improves the Prediction of Intensive Care Unit Length of Stay Following Major Traumatic Injury.Metabolites · 2021Article
- Protein-L-isoaspartate O-methyltransferase is required forHaematologica · 2021Article
- Observational
- Biological and Clinical Factors contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19.Research square · 2021Article
- Trauma-induced coagulopathy.Nature reviews. Disease primers · 2021Review
- The roles of lipids in SARS-CoV-2 viral replication and the host immune response.Journal of lipid research · 2021Review
- Cerebral effects of resuscitation with either epinephrine or vasopressin in an animal model of hemorrhagic shock.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundSevere trauma is associated with massive alterations in metabolism. Thus far, investigations have relied on traditional bioanalytic approaches including calorimetry or nuclear magnetic resonance. However, recent strides in mass spectrometry (MS)-based metabolomics present enhanced analytic opportunities to characterize a wide range of metabolites in the critical care setting.
methodsMS-based metabolomics analyses were performed on plasma samples from severely injured patients' trauma activation field blood and plasma samples obtained during emergency department thoracotomy. These were compared against the metabolic profiles of healthy controls.
resultsFew significant alterations were observed between trauma activation field blood and emergency department thoracotomy patients. In contrast, we identified trauma-dependent metabolic signatures, which support a state of hypercatabolism, driven by sugar consumption, lipolysis and fatty acid use, accumulation of ketone bodies, proteolysis and nucleoside breakdown, which provides carbon and nitrogen sources to compensate for trauma-induced energy consumption and negative nitrogen balance. Unexpectedly, metabolites of bacterial origin (including tricarballylate and citramalate) were detected in plasma from trauma patients.
conclusionIn the future, the correlation between metabolomics adaptation and recovery outcomes could be studied by MS-based approaches, and this work can provide a method for assessing the efficacy of alternative resuscitation strategies.
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