ReviewCurrent opinion in clinical nutrition and metabolic care2015
Latest consensus and update on protein-energy wasting in chronic kidney disease.
Review in Current opinion in clinical nutrition and metabolic care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
147 citing papers in PubMed, 5 syntheses or guidelines pooled it, 288 citations in OpenAlex.
- Frailty risk prediction models in maintenance hemodialysis patients: a systematic review and meta-analysis of studies from China.Renal failure · 2025Pooled it
- Diagnosis, prevalence, and mortality of sarcopenia in dialysis patients: a systematic review and meta-analysis.Journal of cachexia, sarcopenia and muscle · 2022Pooled it
- Low-protein diet for conservative management of chronic kidney disease: a systematic review and meta-analysis of controlled trials.Journal of cachexia, sarcopenia and muscle · 2018Pooled it
- Effect of diet protein restriction on progression of chronic kidney disease: A systematic review and meta-analysis.PloS one · 2018Pooled it
- The association between body mass index and mortality among Asian peritoneal dialysis patients: A meta-analysis.PloS one · 2017Pooled it
- The impact of predialytic oral protein-based supplements on nutritional status and quality of life in hemodialysis patients: a randomized clinical trial.BMC nephrology · 2025Trial
- Education and cooking methods in the management of calcium and PTH serum levels in patients on hemodialysis: a randomized controlled study.Journal of nephrology · 2024Trial
- Effects of a low-protein nutritional formula with dietary counseling in older adults with chronic kidney disease stages 3-5: a randomized controlled trial.BMC nephrology · 2023Trial
- A Randomized, Double-Blind, Crossover Pilot Trial of Rice Endosperm Protein Supplementation in Maintenance Hemodialysis Patients.Scientific reports · 2017Trial
- Prevalence and Overlap of Malnutrition, Sarcopenia and Related Nutritional Syndromes in a Large Haemodialysis Population.Journal of cachexia, sarcopenia and muscle · 2026Article
- Early Post-Transplant Changes in Nutritional Status Predict Long-Term Graft Loss and Mortality.Journal of clinical medicine · 2026Article
- Left atrioventricular coupling index by 2D and 3D echocardiography: association with exercise capacity in chronic kidney disease.Quantitative imaging in medicine and surgery · 2026Article
- Nutritional Knowledge, Dietary Habits, and Nutritional Status of Patients with Chronic Kidney Disease According to Disease Stage.Nutrients · 2026Article
- Association between reduced kidney function and tuberculosis treatment outcomes.BMC infectious diseases · 2026Article
- Nutritional and Metabolic Interventions to Prevent and Treat Protein-Energy Wasting in Nondialysis CKD-Narrative Review.Nutrients · 2026Review
- Crosstalk in the kidney-muscle axis: myokines and muscle-relevant mediators in chronic kidney disease-associated sarcopenia.Frontiers in medicine · 2026Review
- How frailty index impacts death in chronic kidney disease: A retrospective observational investigation.PloS one · 2026Observational
- Effects of a structured nutrition education program on dialysis adequacy and clinical outcomes in maintenance hemodialysis patients.Frontiers in nutrition · 2026Article
- Insulin resistance, metabolic phenotypes, and the obesity paradox: a triglyceride glucose-body mass index framework in partial kidney diseases.Frontiers in endocrinology · 2026Review
- Association between protein-energy wasting and cognitive impairment in maintenance hemodialysis patients.Frontiers in nutrition · 2026Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
purpose of reviewProtein-energy wasting (PEW) is a state of metabolic and nutritional derangements in chronic disease states including chronic kidney disease (CKD). Cumulative evidence suggests that PEW, muscle wasting and cachexia are common and strongly associated with mortality in CKD, which is reviewed here. RECENT
findingsThe malnutrition-inflammation score (KALANTAR Score) is among the comprehensive and outcome-predicting nutritional scoring tools. The association of obesity with poor outcomes is attenuated across more advanced CKD stages and eventually reverses in the form of obesity paradox. Frailty is closely associated with PEW, muscle wasting and cachexia. Muscle loss shows stronger associations with unfavorable outcomes than fat loss. Adequate energy supplementation combined with low-protein diet for the management of CKD may prevent the development of PEW and can improve adherence to low-protein diet, but dietary protein requirement may increase with aging and is higher under dialysis therapy. Phosphorus burden may lead to poor outcomes. The target serum bicarbonate concentration is normal range and at least 23 mEq/l for nondialysis-dependent and dialysis-dependent CKD patients, respectively. A benefit of exercise is suggested but not yet conclusively proven. SUMMARY: Prevention and treatment of PEW should involve individualized and integrated approaches to modulate identified risk factors and contributing comorbidities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.