Evidence map›Paper›PMID 25807259›Full record

ArticlePloS one2015

Sex differences in peripheral mu-opioid receptor mediated analgesia in rat orofacial persistent pain model.

Xiaofeng Bai, Xia Zhang, Yanshu Li, Li Lu, Bo Li, Xiaofan He

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Plasma Pro-Enkephalin A and Ischemic Stroke Risk: The Reasons for Geographic and Racial Differences in Stroke Cohort.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022
    Article
  12. Review
  13. Article
  14. Peripherally Acting Opioids in Orofacial Pain.Frontiers in neuroscience · 2021
    Review
  15. Article
  16. Article
  17. Neuronal and glial factors contributing to sex differences in opioid modulation of pain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Review
  18. Impact of sex on pain and opioid analgesia: a review.Current opinion in behavioral sciences · 2018
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiaofeng BaiAssociate Professor, Department of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, China Medical University, 117 North Nanjing Street, Shenyang, P. R. of China, 110002.
Xia ZhangAssociate Professor, Department of Anesthesiology, School & Hospital of Stomatology, China Medical University, 117 North Nanjing Street, Shenyang, P. R. of China, 110002.
Yanshu LiAssistant Professor, Department of Cell Biology, China Medical University, 92 Bei'er Road, Shenyang, P. R. of China, 110001.
Li LuProfessor, Department of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, China Medical University, 117 North Nanjing Street, Shenyang, P. R. of China, 110002.
Bo LiAssociate Professor, Department of Oral Anatomy and Physiology, School of Stomatology, China Medical University, 117 North Nanjing Street, Shenyang, P. R. of China, 110002.
Xiaofan HeAssistant Professor, Department of Anesthesiology, School & Hospital of Stomatology, China Medical University, 117 North Nanjing Street, Shenyang, P. R. of China, 110002.
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unilateral ligation of the tendon of anterior superficial part of rat masseter muscle (TASM) leads to long-lasting allodynia. Sex differences in peripheral mu-opioid receptor (MOR)-mediated analgesia under persistent myogenic pain are not well understood. In this study, we examined (1) whether locally applied MOR agonists attenuate persistent pain following TASM ligation in a sex dependent manner, (2) whether there are sex differences of MOR expression changes in rat trigeminal ganglia (TG). The effects of MOR agonist, D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt (DAMGO), were assessed 14 days after TASM ligation in male, female and orchidectomized (GDX) male rats. MOR mRNA and protein levels in TG 14 days following tendon ligation were also determined. The mechanical thresholds of the injured side were significantly decreased in both male and female rats, from 3 days to 28 days after TASM ligation. A10 μg DAMGO significantly attenuated allodynia in male rats. A 10-fold higher dose of DAMGO was required in female and GDX male rats to produce the level of anti- allodynia achieved in male rats. The level of MOR mRNA in TG from male rats was significantly greater 14 days after TASM ligation compared with the sham-operated male rats, but not from female and GDX male rats. After TASM ligation, males had significantly more MOR immunoreactivity in TG compared to sham-operated males. The MOR levels increased to 181.8% of the sham level in male rats receiving tendon injury. But there was no significant change in female rats receiving tendon injury compared to the sham female rats. Taken together, our data suggest that there were sex differences in the effects of peripheral MOR agonists between male and female rats under TASM ligation developing long-lasting pain condition, which is partly mediated by sex differences in the changes of MOR expressions and testosterone is an important factor in the regulation of MOR.

Indexed as

Analgesics, OpioidAnimalsBehavior, AnimalDisease Models, AnimalEnkephalin, Ala(2)-MePhe(4)-Gly(5)-Facial PainFemaleHyperalgesiaImmunohistochemistryMaleOrchiectomyRatsRats, Sprague-DawleyReal-Time Polymerase Chain ReactionReceptors, Opioid, muRNA, MessengerAnalgesics, OpioidEnkephalin, Ala(2)-MePhe(4)-Gly(5)-Receptors, Opioid, muRNA, Messenger

Identifiers

PMID25807259
PMCPMC4373836
OpenAlexW2086460638

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.