Evidence map›Paper›PMID 25807081›Full record

ArticlePloS one2015

Long-term dietary supplementation of pomegranates, figs and dates alleviate neuroinflammation in a transgenic mouse model of Alzheimer's disease.

Musthafa Mohamed Essa, Selvaraju Subash, Mohammed Akbar, Samir Al-Adawi, Gilles J Guillemin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.

  1. Pooled it
  2. Valorization of Date Palm (Molecules (Basel, Switzerland) · 2026
    Review
  3. Article
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  5. Article
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  9. Review
  10. Article
  11. Article
  12. Pomegranate (Molecules (Basel, Switzerland) · 2024
    Review
  13. Review
  14. Article
  15. Physicochemistry, Nutritional, and Therapeutic Potential ofDrug design, development and therapy · 2024
    Review
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Musthafa Mohamed EssaDept of Food Science and Nutrition, College of Agriculture and Marine Sciences, Sultan Qaboos University, Muscat, Oman; Ageing and Dementia Research Group, Sultan Qaboos University, Muscat, Oman; Neuropharmacology group, MND and Neurodegenerative Diseases Research Centre, Macquarie University, Sydney, NSW, Australia.
Selvaraju SubashDept of Food Science and Nutrition, College of Agriculture and Marine Sciences, Sultan Qaboos University, Muscat, Oman; Ageing and Dementia Research Group, Sultan Qaboos University, Muscat, Oman.
Mohammed AkbarSection of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, United States of America.
Samir Al-AdawiAgeing and Dementia Research Group, Sultan Qaboos University, Muscat, Oman; College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Gilles J GuilleminNeuropharmacology group, MND and Neurodegenerative Diseases Research Centre, Macquarie University, Sydney, NSW, Australia.
Sultan Qaboos University · OMMacquarie University · AUNational Institute on Alcohol Abuse and Alcoholism · US

Funding

Alcohol Metabolism, Functional Consequences, Apoptosis Signaling Pathways, and Organ DamageZIAAA000036 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI SONG, BYOUNG-JOON · 2009 to 2025
$14.8M
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a devastating age-related neurodegenerative disease with no specific treatment at present. The APPsw/Tg2576 mice exhibit age-related deterioration in memory and learning as well as amyloid-beta (Aβ) accumulation, and this mouse strain is considered an effective model for studying the mechanism of accelerated brain aging and senescence. The present study was aimed to investigate the beneficial effects of dietary supplements pomegranate, figs, or the dates on suppressing inflammatory cytokines in APPsw/Tg2576 mice. Changes in the plasma cytokines and Aβ, ATP, and inflammatory cytokines were investigated in the brain of transgenic mice. Significantly enhanced levels of inflammatory cytokines IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-9, IL-10, TNF-α and Eotaxin activity were decreased by administration of the diet supplements containing pomegranates, figs, or dates. In addition, putative delays in the formation of senile plaques, as indicated by a decreasing tendency of brain Aβ1-40 and Aβ1-42 contents, were observed. Thus, novel results mediated by reducing inflammatory cytokines during aging may represent one mechanism by which these supplements exert their beneficial effects against neurodegenerative diseases such as AD.

Indexed as

Adenosine TriphosphateAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBrainCytokinesDietary SupplementsDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFemaleFicusFruitLythraceaeMiceMice, TransgenicPhoeniceaeAdenosine TriphosphateAmyloid beta-PeptidesCytokines

Identifiers

PMID25807081
PMCPMC4373715
OpenAlexW2038656308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.