ArticleEndocrinology2015
Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice.
Article in Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- Time-restricted feeding extends healthspan in both sexes and lifespan in male C57BL/6 J mice.Nature aging · 2026Article
- Sex impact on daily activity and physiological, metabolic and hormonal responses to different photoperiod regimens in diet-induced obese fischer 344 rats.Journal of physiology and biochemistry · 2025Article
- Time-Restricted Feeding Extends Healthspan in Female and Lifespan in Male C57BL/6J Mice.bioRxiv : the preprint server for biology · 2025Article
- Sex differences in the redox response to fine particulate matter (PMPhysiological reports · 2025Article
- Light phase feeding and estradiol reverse ovariectomy-induced alterations in metabolism and liver clock gene expression in rat.Biogerontology · 2025Article
- The Effects of Constant Light and Running-Wheel Access in Middle-Aged Female C57BL6/J Mice.Sleep science (Sao Paulo, Brazil) · 2025Article
- Elevated body roundness index increases the risk of cardiovascular disease in Chinese patients with circadian syndrome.Frontiers in endocrinology · 2025Article
- Circadian regulation of liver metabolism: experimental approaches in human, rodent, and cellular models.American journal of physiology. Cell physiology · 2023Review
- Article
- Treating menopause - MHT and beyond.Nature reviews. Endocrinology · 2022Review
- Light Environment Influences Developmental Programming of the Metabolic and Visual Systems in Mice.Investigative ophthalmology & visual science · 2021Article
- Hypothalamic REV-ERB nuclear receptors control diurnal food intake and leptin sensitivity in diet-induced obese mice.The Journal of clinical investigation · 2021Article
- Removal of melatonin receptor type 1 signalling induces dyslipidaemia and hormonal changes in mice subjected to environmental circadian disruption.Endocrinology, diabetes & metabolism · 2021Article
- Impact of Social Jetlag on Weight Change in Adults: Korean National Health and Nutrition Examination Survey 2016-2017.International journal of environmental research and public health · 2020Article
- The Disruption of Liver Metabolic Circadian Rhythms by a Cafeteria Diet Is Sex-Dependent in Fischer 344 Rats.Nutrients · 2020Article
- Circadian Clock, Time-Restricted Feeding and Reproduction.International journal of molecular sciences · 2020Review
- Circadian misalignment alters insulin sensitivity during the light phase and shifts glucose tolerance rhythms in female mice.PloS one · 2019Article
- Estradiol alters body temperature regulation in the female mouse.Temperature (Austin, Tex.) · 2018Article
- Melanocortin 4 receptor is not required for estrogenic regulations on energy homeostasis and reproduction.Metabolism: clinical and experimental · 2017Article
- Inhibition of expression of the circadian clock gene Period causes metabolic abnormalities including repression of glycometabolism in Bombyx mori cells.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 2 countries.
Funding
Abstract
Circadian disruption has become a significant factor contributing to the epidemics of obesity and insulin resistance. However, interventions to treat metabolic dysfunctions induced by circadian disruptions are limited. The ovarian hormone, estrogen, produces important antiobesity and antidiabetic effects in female animals and has profound effects on daily behavioral rhythms. Here, we show that in female mice depleted with endogenous estrogens, a jet-lag paradigm induced visceral fat accumulation and systemic insulin resistance, which were associated with altered expression of multiple circadian genes in the visceral fat depot. Interestingly, all these jet-lag-induced deficits were completely rescued in female mice supplemented with exogenous estrogens. We further examined 24-hour oscillations of circadian genes in adipose tissues in female mice with estrogen depletion or replacement and showed that expression levels of the circadian gene, period circadian protein homolog 2, oscillate in visceral adipose tissue in an estrogen-dependent manner. Together, our results indicate that estrogens interact with the intrinsic circadian clock in adipose tissue and prevent abnormal lipid accumulation caused by circadian disruptions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.