ArticlePain management2015
Placebo analgesia: understanding the mechanisms.
Article in Pain management, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 76 citations in OpenAlex.
- Tailored transcutaneous electrical nerve stimulation improves dysesthesia in individuals with spinal cord injury: A randomized N-of-1 trial.The journal of spinal cord medicine · 2026Trial
- Comparison of two tDCS protocols on pain and EEG alpha-2 oscillations in women with fibromyalgia.Scientific reports · 2020Trial
- Influence of skin cold sensation threshold in the occurrence of dental sensitivity during dental bleaching: a placebo controlled clinical trial.Journal of applied oral science : revista FOB · 2018Trial
- Exploring the Effectiveness of External Use of Bach Flower Remedies on Carpal Tunnel Syndrome: A Pilot Study.Journal of evidence-based complementary & alternative medicine · 2017Trial
- Placebo analgesia persistence: evaluating behavioural stability in repeated trials.Communications biology · 2026Article
- The Role of Oxytocin and Sex in Analgesic Placebo-Response: Exploratory Analysis from a Sham Randomized Clinical Trial in Chronic Back-Pain Patients.Journal of clinical medicine · 2025Article
- Combining mindfulness intervention and open-label placebo treatment for chronic pain: a protocol for a feasibility study.Pilot and feasibility studies · 2025Article
- Effects of Repetitive Transcranial Magnetic Stimulation Applied over the Primary Motor Cortex on the Offset Analgesia Phenomenon.Life (Basel, Switzerland) · 2025Article
- Function and biochemistry of the dorsolateral prefrontal cortex during placebo analgesia: how the certainty of prior experiences shapes endogenous pain relief.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Stimulus-independent and stimulus-dependent neural networks underpin placebo analgesia responsiveness in humans.Communications biology · 2023Article
- The Temporal Modulation of Nocebo Hyperalgesia in a Model of Sustained Pain.Frontiers in psychiatry · 2022Article
- Brainstem Mechanisms of Pain Modulation: A within-Subjects 7T fMRI Study of Placebo Analgesic and Nocebo Hyperalgesic Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Effects of Brief Mindfulness Interventions on the Interference Induced by Experimental Heat Pain on Cognition in Healthy Individuals.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Open-Label Placebo Interventions With Drinking Water and Their Influence on Perceived Physical and Mental Well-Being.Frontiers in psychology · 2021Article
- Relationship Between Pain Reduction and Improvement in Health-Related Quality of Life in Patients with Knee Pain Due to Osteoarthritis Receiving Duloxetine: Exploratory Post Hoc Analysis of a Japanese Phase 3 Randomized Study.Journal of pain research · 2020Article
- Pain Modulation: From Conditioned Pain Modulation to Placebo and Nocebo Effects in Experimental and Clinical Pain.International review of neurobiology · 2018Review
- Contextually Aided Recovery (CARe): a scientific theory for innate healing.Chiropractic & manual therapies · 2017Article
- [Placebo response - Mechanisms and clinical applications].Schmerz (Berlin, Germany) · 2016Review
- Placebo, nocebo, and neuropathic pain.Pain · 2016Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Expectations of pain relief drive placebo analgesia. Understanding how expectations of improvement trigger distinct biological systems to shape therapeutic analgesic outcomes has been the focus of recent pharmacologic and neuroimaging studies in the field of pain. Recent findings indicate that placebo effects can imitate the actions of real painkillers and promote the endogenous release of opioids and nonopioids in humans. Social support and observational learning also contribute to placebo analgesic effects. Distinct psychological traits can modulate expectations of analgesia, which facilitate brain pain control mechanisms involved in pain reduction. Many studies have highlighted the importance and clinical relevance of these responses. Gaining deeper understanding of these pain modulatory mechanisms has important implications for personalizing patient pain management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.