ArticleHeredity2015
Conservatism and novelty in the genetic architecture of adaptation in Heliconius butterflies.
Article in Heredity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Genetic parallelism underpins convergent mimicry coloration in Lepidoptera across 120 million years of evolution.PLoS biology · 2026Article
- The genetics and evolution of moth melanism in the absence of strong natural selection.National science review · 2026Article
- WntA expression and wing transcriptomics illuminate the evolution of stripe patterns in skipper butterflies.Biology open · 2025Article
- A long noncoding RNA at theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Subtle Introgression Footprints at the End of the Speciation Continuum in a Clade of Heliconius Butterflies.Molecular biology and evolution · 2023Article
- Association mapping of colour variation in a butterfly provides evidence that a supergene locks together a cluster of adaptive loci.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Article
- Inversion breakpoints and the evolution of supergenes.Molecular ecology · 2021Review
- Genomic variation, population history and within-archipelago adaptation between island bird populations.Royal Society open science · 2021Article
- Deep Convergence, Shared Ancestry, and Evolutionary Novelty in the Genetic Architecture ofGenetics · 2020Article
- The combined use of raw and phylogenetically independent methods of outlier detection uncovers genome-wide dynamics of local adaptation in a lizard.Ecology and evolution · 2019Article
- The genetic architecture of adaptation: convergence and pleiotropy in Heliconius wing pattern evolution.Heredity · 2019Article
- Discrete or indiscrete? Redefining the colour polymorphism of the land snail Cepaea nemoralis.Heredity · 2019Article
- Diversity in warning coloration: selective paradox or the norm?Biological reviews of the Cambridge Philosophical Society · 2019Review
- Subtle variation in size and shape of the whole forewing and the red band among co-mimics revealed by geometric morphometric analysis inEcology and evolution · 2018Article
- Macroevolutionary shifts ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Polymorphism at a mimicry supergene maintained by opposing frequency-dependent selection pressures.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Young inversion with multiple linked QTLs under selection in a hybrid zone.Nature ecology & evolution · 2017Article
- Waiting in the wings: what can we learn about gene co-option from the diversification of butterfly wing patterns?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
Abstract
Understanding the genetic architecture of adaptive traits has been at the centre of modern evolutionary biology since Fisher; however, evaluating how the genetic architecture of ecologically important traits influences their diversification has been hampered by the scarcity of empirical data. Now, high-throughput genomics facilitates the detailed exploration of variation in the genome-to-phenotype map among closely related taxa. Here, we investigate the evolution of wing pattern diversity in Heliconius, a clade of neotropical butterflies that have undergone an adaptive radiation for wing-pattern mimicry and are influenced by distinct selection regimes. Using crosses between natural wing-pattern variants, we used genome-wide restriction site-associated DNA (RAD) genotyping, traditional linkage mapping and multivariate image analysis to study the evolution of the architecture of adaptive variation in two closely related species: Heliconius hecale and H. ismenius. We implemented a new morphometric procedure for the analysis of whole-wing pattern variation, which allows visualising spatial heatmaps of genotype-to-phenotype association for each quantitative trait locus separately. We used the H. melpomene reference genome to fine-map variation for each major wing-patterning region uncovered, evaluated the role of candidate genes and compared genetic architectures across the genus. Our results show that, although the loci responding to mimicry selection are highly conserved between species, their effect size and phenotypic action vary throughout the clade. Multilocus architecture is ancestral and maintained across species under directional selection, whereas the single-locus (supergene) inheritance controlling polymorphism in H. numata appears to have evolved only once. Nevertheless, the conservatism in the wing-patterning toolkit found throughout the genus does not appear to constrain phenotypic evolution towards local adaptive optima.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.