ArticleScientific reports2015
The effect of music performance on the transcriptome of professional musicians.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07653594 (TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE): A Single Arm Pilot Study
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Sensogenomics of music and Alzheimer's disease: An interdisciplinary view from neuroscience, transcriptomics, and epigenomics.Frontiers in aging neuroscience · 2023Pooled it
- Shared Transcriptomic and Epigenomic Signatures Between Traumatic Brain Injury and Music Exposure: An Integrative Proof of Concept.ASN neuro · 2026Article
- Does leisure activity matter for epigenetic aging? Analyses of arts engagement and physical activity in the UK Household Longitudinal Study.Innovation in aging · 2026Article
- Does frequency or diversity of leisure activity matter more for epigenetic ageing? Analyses of arts engagement and physical activity.medRxiv : the preprint server for health sciences · 2025Article
- Rhythmic Roots: The Adaptive Functions of Vocal Isochrony and Its Role in Human Music and Language Evolution.Psihologijske teme = Psychological themes = Psychological topics · 2025Article
- A Cross-over Pilot Study on the Effects of Classical Guitar Instruction on Motor and Non-Motor Symptoms in People with Parkinson's Disease.Neuroscience insights · 2025Article
- Music compensates for altered gene expression in age-related cognitive disorders.Scientific reports · 2023Article
- Genetic factors and shared environment contribute equally to objective singing ability.iScience · 2022Article
- Ventral tegmental area dopaminergic action in music therapy for post-traumatic stress disorder: A literature review.Frontiers in psychology · 2022Review
- Music Aptitude, Training, and Cognitive Transfer: A Mini-Review.Frontiers in psychology · 2022Review
- Review
- Human Genomics and the Biocultural Origin of Music.International journal of molecular sciences · 2021Review
- Music-listening regulates human microRNA expression.Epigenetics · 2021Article
- Review
- Typologies of Adolescent Musicians and Experiences of Performance Anxiety Among Instrumental Learners.Frontiers in psychology · 2021Article
- How far musicality and perfect pitch are derived from genetic factors?Journal of applied genetics · 2020Review
- Shared transcriptional responses to con- and heterospecific behavioral antagonists in a wild songbird.Scientific reports · 2020Article
- Birdsong as a window into language origins and evolutionary neuroscience.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Article
- Are We Doing More Than We Know? Possible Mechanisms of Response to Music Therapy.Frontiers in medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Music performance by professional musicians involves a wide-spectrum of cognitive and multi-sensory motor skills, whose biological basis is unknown. Several neuroscientific studies have demonstrated that the brains of professional musicians and non-musicians differ structurally and functionally and that musical training enhances cognition. However, the molecules and molecular mechanisms involved in music performance remain largely unexplored. Here, we investigated the effect of music performance on the genome-wide peripheral blood transcriptome of professional musicians by analyzing the transcriptional responses after a 2-hr concert performance and after a 'music-free' control session. The up-regulated genes were found to affect dopaminergic neurotransmission, motor behavior, neuronal plasticity, and neurocognitive functions including learning and memory. Particularly, candidate genes such as SNCA, FOS and DUSP1 that are involved in song perception and production in songbirds, were identified, suggesting an evolutionary conservation in biological processes related to sound perception/production. Additionally, modulation of genes related to calcium ion homeostasis, iron ion homeostasis, glutathione metabolism, and several neuropsychiatric and neurodegenerative diseases implied that music performance may affect the biological pathways that are otherwise essential for the proper maintenance of neuronal function and survival. For the first time, this study provides evidence for the candidate genes and molecular mechanisms underlying music performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.