ArticleRNA biology2015
Sense overlapping transcripts in IS1341-type transposase genes are functional non-coding RNAs in archaea.
Article in RNA biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Archaea express circular isoforms of IS200/IS605-associated ωRNAs.Frontiers in microbiology · 2025Article
- Evolutionary mining and functional characterization of TnpB nucleases identify efficient miniature genome editors.Nature biotechnology · 2024Article
- Extracellular vesicle formation inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Transposons and CRISPR: Rewiring Gene Editing.Biochemistry · 2023Article
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- Article
- Transposon-encoded nucleases use guide RNAs to selfishly bias their inheritance.bioRxiv : the preprint server for biology · 2023Article
- Characterization of an archaeal virus-host system reveals massive genomic rearrangements in a laboratory strain.Frontiers in microbiology · 2023Article
- Article
- The widespread IS200/IS605 transposon family encodes diverse programmable RNA-guided endonucleases.Science (New York, N.Y.) · 2021Article
- Article
- CORAZON: a web server for data normalization and unsupervised clustering based on expression profiles.BMC research notes · 2020Article
- CRISPR-Based Diagnosis of Infectious and Noninfectious Diseases.Biological procedures online · 2020Review
- The Primary Antisense Transcriptome ofGenes · 2019Article
- Article
- A transposon-derived small RNA regulates gene expression in Salmonella Typhimurium.Nucleic acids research · 2017Article
- Diversity and evolution of class 2 CRISPR-Cas systems.Nature reviews. Microbiology · 2017Article
- Genome-wide identification of transcriptional start sites in the haloarchaeon Haloferax volcanii based on differential RNA-Seq (dRNA-Seq).BMC genomics · 2016Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The existence of sense overlapping transcripts that share regulatory and coding information in the same genomic sequence shows an additional level of prokaryotic gene expression complexity. Here we report the discovery of ncRNAs associated with IS1341-type transposase (tnpB) genes, at the 3'-end of such elements, with examples in archaea and bacteria. Focusing on the model haloarchaeon Halobacterium salinarum NRC-1, we show the existence of sense overlapping transcripts (sotRNAs) for all its IS1341-type transposases. Publicly available transcriptome compendium show condition-dependent differential regulation between sotRNAs and their cognate genes. These sotRNAs allowed us to find a UUCA tetraloop motif that is present in other archaea (ncRNA family HgcC) and in a H. salinarum intergenic ncRNA derived from a palindrome associated transposable elements (PATE). Overexpression of one sotRNA and the PATE-derived RNA harboring the tetraloop motif improved H. salinarum growth, indicating that these ncRNAs are functional.
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