A quantitative study on changes of the myelinated fibers in the cerebral cortex of cortical dysplasia rats.

Xuntai Ma, Yong Tang, Yang Lv, Oumei Cheng, Yong Yan

Abstract read

In one paragraph

Article in Neural regeneration research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact, top 97% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed, 1 citations in OpenAlex.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xuntai MaDepartment of Neurology, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China.

Yong TangDepartment of Histology and Embryology, Institute of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China ; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Yang LvDepartment of Geriatrics, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Oumei ChengDepartment of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Yong YanDepartment of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

First Affiliated Hospital of Chongqing Medical University · CNChongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An animal model of cortical dysplasia was established through X-ray irradiation induced subcortical heterotopic nodules in rats. Transmission electron microscopy detection of the ultrastructure and the stereology examination showed that there was a significant decrease in cerebral white matter and hippocampal volume, the total volume, volume density, length density and total length of the myelinated fibers in the white matter of cortical dysplasia rats. Subcortical heterotopic nodules of the hippocampal CA1 region and synaptic number density in the CA3 region were reduced compared with normal rats. Our experimental findings indicate that erosed subcortical heterotopic nodules, decreased total length of myelinated nerve fibers and demyelination directly lead to a reduction of white matter volume.

Indexed as

cortical dysplasiaheterotopic nodulesmedullary sheathmyelinated fibersstereologywhite matter

Identifiers

PMID25806067

DOI10.3969/j.issn.1673-5374.2012.04.005

PMCPMC4353098

OpenAlexW939630551

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LicenceCC BY-NC-SA

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.