Evidence map›Paper›PMID 25806064›Full record

ArticleNeural regeneration research2012

Reconstruction of the adenosine system by bone marrow-derived mesenchymal stem cell transplantation.

Huicong Kang, Qi Hu, Xiaoyan Liu, Yinhe Liu, Feng Xu, Xiang Li, Suiqiang Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Huicong KangDepartment of Neurology, Tongji Hospital of Tongji Medical University, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China.
Qi HuDepartment of Neurology, Tongji Hospital of Tongji Medical University, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China.
Xiaoyan LiuDepartment of Neurology, Tongji Hospital of Tongji Medical University, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China.
Yinhe LiuMinistry of Water Resources of China, Beijing 100000, China.
Feng XuDepartment of Neurology, Tongji Hospital of Tongji Medical University, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China.
Xiang LiDepartment of Neurology, Tongji Hospital of Tongji Medical University, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China.
Suiqiang ZhuDepartment of Neurology, Tongji Hospital of Tongji Medical University, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China.
Huazhong University of Science and Technology · CNTongji Hospital · CNMinistry of Water Resources of the People's Republic of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, we transplanted bone marrow-derived mesenchymal stem cells into the CA3 area of the hippocampus of chronic epilepsy rats kindled by lithium chloride-pilocarpine. Immunofluorescence and western blotting revealed an increase in adenosine A1 receptor expression and a decrease in adenosine A2a receptor expression in the brain tissues of epileptic rats 3 months after transplantation. Moreover, the imbalance in the A1 adenosine receptor/A2a adenosine receptor ratio was improved. Electroencephalograms showed that frequency and amplitude of spikes in the hippocampus and frontal lobe were reduced. These results suggested that mesenchymal stem cell transplantation can reconstruct the normal function of the adenosine system in the brain and greatly improve epileptiform discharges.

Indexed as

adenosine systembone marrow-derived mesenchymal stem cellscell transplantationchronic epilepsyelectroencephalogramimmunohistochemistryreconstruction

Identifiers

PMID25806064
PMCPMC4353095
OpenAlexW257437686

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.