ArticleFrontiers in microbiology2015
The use of evolutionary approaches to understand single cell genomes.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Homologous Recombination in Core Genomes Facilitates Marine Bacterial Adaptation.Applied and environmental microbiology · 2018Article
- Fundamental differences in diversity and genomic population structure between Atlantic and Pacific Prochlorococcus.The ISME journal · 2017Article
- Ecological Genomics of the Uncultivated Marine Roseobacter Lineage CHAB-I-5.Applied and environmental microbiology · 2016Article
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1 author.
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Abstract
The vast majority of environmental bacteria and archaea remain uncultivated, yet their genome sequences are rapidly becoming available through single cell sequencing technologies. Reconstructing metabolism is one common way to make use of genome sequences of ecologically important bacteria, but molecular evolutionary analysis is another approach that, while currently underused, can reveal important insights into the function of these uncultivated microbes in nature. Because genome sequences from single cells are often incomplete, metabolic reconstruction based on genome content can be compromised. However, this problem does not necessarily impede the use of phylogenomic and population genomic approaches that are based on patterns of polymorphisms and substitutions at nucleotide and amino acid sites. These approaches explore how various evolutionary forces act to assemble genetic diversity within and between lineages. In this mini-review, I present examples illustrating the benefits of analyzing single cell genomes using evolutionary approaches.
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