Evidence map›Paper›PMID 25805980›Full record

ArticleFrontiers in behavioral neuroscience2015

Stronger pharmacological cortisol suppression and anticipatory cortisol stress response in transient global amnesia.

Martin Griebe, Frauke Nees, Benjamin Gerber, Anne Ebert, Herta Flor, Oliver T Wolf, Achim Gass, Michael G Hennerici, Kristina Szabo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Martin GriebeDepartment of Neurology, UniversitätsMedizin Mannheim, Heidelberg University , Mannheim , Germany.
Frauke NeesDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Heidelberg University , Mannheim , Germany.
Benjamin GerberDepartment of Neurology, UniversitätsMedizin Mannheim, Heidelberg University , Mannheim , Germany.
Anne EbertDepartment of Neurology, UniversitätsMedizin Mannheim, Heidelberg University , Mannheim , Germany.
Herta FlorDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Heidelberg University , Mannheim , Germany.
Oliver T WolfDepartment of Cognitive Psychology, Institute of Cognitive Neuroscience, Ruhr-University Bochum , Bochum , Germany.
Achim GassDepartment of Neurology, UniversitätsMedizin Mannheim, Heidelberg University , Mannheim , Germany.
Michael G HennericiDepartment of Neurology, UniversitätsMedizin Mannheim, Heidelberg University , Mannheim , Germany.
Kristina SzaboDepartment of Neurology, UniversitätsMedizin Mannheim, Heidelberg University , Mannheim , Germany.
Heidelberg University · DECentral Institute of Mental Health · DERuhr University Bochum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transient global amnesia (TGA) is a disorder characterized by a sudden attack of severe anterograde memory disturbance that is frequently preceded by emotional or physical stress and resolves within 24 h. By using MRI following the acute episode in TGA patients, small lesions in the hippocampus have been observed. Hence, it has been hypothesized that the disorder is caused by a stress-related transient inhibition of memory formation in the hippocampus. To study the factors that may link stress and TGA, we measured the cortisol day-profile, the dexamethasone feedback inhibition and the effect of experimental exposure to stress on cortisol levels (using the socially evaluated cold pressor test and a control procedure) in 20 patients with a recent history of TGA and in 20 healthy controls. We used self-report scales of depression, anxiety and stress, and a detailed neuropsychological assessment to characterize our collective. We did not observe differences in mean cortisol levels in the cortisol day-profile between the two groups. After administration of low-dose dexamethasone, TGA patients showed significantly stronger cortisol suppression in the daytime profile compared to the control group (p = 0.027). The mean salivary cortisol level was significantly higher in the TGA group prior to and after the experimental stress exposure (p = 0.008 and 0.010 respectively), as well as prior to and after the control condition (p = 0.022 and 0.024, respectively). The TGA group had higher scores of depressive symptomatology (p = 0.021) and anxiety (p = 0.007), but the groups did not differ in the neuropsychological assessment. Our findings of a stronger pharmacological suppression and higher cortisol levels in anticipation of experimental stress in participants with a previous TGA indicate a hypersensitivity of the HPA axis. This suggests that an individual stress sensitivity might play a role in the pathophysiology of TGA.

Indexed as

cortisolhippocampusmemorystresstransient global amnesia

Identifiers

PMID25805980
PMCPMC4353300
OpenAlexW2153115187

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.