Evidence map›Paper›PMID 25805975›Full record

ArticleFrontiers in systems neuroscience2015

Neural correlates of high-risk behavior tendencies and impulsivity in an emotional Go/NoGo fMRI task.

Matthew R G Brown, James R A Benoit, Michal Juhás, R M Lebel, Marnie MacKay, Ericson Dametto, Peter H Silverstone, Florin Dolcos, Serdar M Dursun, Andrew J Greenshaw

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in systems neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Matthew R G BrownDepartment of Psychiatry, University of Alberta Edmonton, AB, Canada.
James R A BenoitDepartment of Psychiatry, University of Alberta Edmonton, AB, Canada.
Michal JuhásDepartment of Psychiatry, University of Alberta Edmonton, AB, Canada.
R M LebelDepartment of Biomedical Engineering, University of Alberta Edmonton, AB, Canada.
Marnie MacKayDepartment of Psychiatry, University of Alberta Edmonton, AB, Canada.
Ericson DamettoDepartment of Psychiatry, University of Alberta Edmonton, AB, Canada.
Peter H SilverstoneDepartment of Psychiatry, University of Alberta Edmonton, AB, Canada.
Florin DolcosDepartment of Psychiatry, University of Alberta Edmonton, AB, Canada ; Department of Psychology, Neuroscience Program, and the Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign Urbana-Champaign, IL, USA.
Serdar M DursunDepartment of Psychiatry, University of Alberta Edmonton, AB, Canada.
Andrew J GreenshawDepartment of Psychiatry, University of Alberta Edmonton, AB, Canada.
University of Alberta · CAUniversity of Illinois Urbana-Champaign · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Improved neuroscientific understanding of high-risk behaviors such as alcohol binging, drug use, and unsafe sex will lead to therapeutic advances for high-risk groups. High-risk behavior often occurs in an emotionally-charged context, and behavioral inhibition and emotion regulation play important roles in risk-related decision making. High impulsivity is an important potential contributor to high-risk behavior tendencies. We explored the relationships between high-risk behavior tendencies, impulsivity, and fMRI brain activations in an emotional Go/NoGo task. This task presented emotional distractor pictures (aversive vs. neutral) simultaneously with Go/NoGo stimuli (square vs. circle) that required a button press or withholding of the press, respectively. Participants' risk behavior tendencies were assessed with the Cognitive Appraisal of Risky Events (CARE) scale. The Barratt Impulsivity Scale 11 (BIS) was used to assess participant impulsivity. Individuals with higher CARE risk scores exhibited reduced activation related to response inhibition (NoGo-Go) in right orbital frontal cortex (OFC) and ventromedial prefrontal cortex. These regions did not show a significant relationship with impulsivity scores. Conversely, more impulsive individuals showed reduced emotion-related activity (aversive-neutral distractors) in dorsomedial prefrontal cortex, perigenual anterior cingulate cortex, and right posterior OFC. There were distinct neural correlates of high-risk behavior tendency and impulsivity in terms of brain activity in the emotional Go/NoGo task. This dissociation supports the conception of high-risk behavior tendency as a distinct construct from that of impulsivity. Our results suggest that treatment for high-risk behavior may be more effective with a nuanced approach that does not conflate high impulsivity necessarily with high-risk behavior tendencies.

Indexed as

BISCAREemotional Go/NoGofMRIhigh-risk behaviorimpulsivity

Identifiers

PMID25805975
PMCPMC4354310
OpenAlexW2008907414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.