ArticleFrontiers in neural circuits2015
Insulin signaling is acutely required for long-term memory in Drosophila.
Article in Frontiers in neural circuits, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- The insulin-like peptide INS-27 mediates a muscle-to-neuron feedback signal coupling muscle activity with AMPA receptor trafficking.PLoS genetics · 2025Article
- A brief history of insect neuropeptide and peptide hormone research.Cell and tissue research · 2025Review
- Large-language models facilitate discovery of the molecular signatures regulating sleep and activity.Nature communications · 2024Article
- Octopamine integrates the status of internal energy supply into the formation of food-related memories.eLife · 2024Article
- The diverse roles of insulin signaling in insect behavior.Frontiers in insect science · 2024Review
- FOXO inBiology · 2023Article
- Local autocrine plasticity signaling in single dendritic spines by insulin-like growth factors.Science advances · 2023Article
- The Insulin Receptor: An Important Target for the Development of Novel Medicines and Pesticides.International journal of molecular sciences · 2022Review
- Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions.Open biology · 2022Review
- Anti-Obesity Efficacy ofInternational journal of molecular sciences · 2022Article
- Nutrient responding peptide hormone CCHamide-2 consolidates appetitive memory.Frontiers in behavioral neuroscience · 2022Article
- Reduced Insulin Signaling Targeted to Serotonergic Neurons but Not Other Neuronal Subtypes Extends Lifespan inFrontiers in aging neuroscience · 2022Article
- Insulin and Memory in Invertebrates.Frontiers in behavioral neuroscience · 2022Review
- A neural circuit linking two sugar sensors regulates satiety-dependent fructose drive inScience advances · 2021Article
- Article
- Effect of photoperiod and light intensity on learning ability and memory formation of the pond snail Lymnaea stagnalis.Invertebrate neuroscience : IN · 2020Article
- Insulin signaling represents a gating mechanism between different memory phases in Drosophila larvae.PLoS genetics · 2020Article
- Neuromedin U signaling regulates retrieval of learned salt avoidance in a C. elegans gustatory circuit.Nature communications · 2020Article
- Exploiting Common Aspects of Obesity and Alzheimer's Disease.Frontiers in human neuroscience · 2020Review
- Intellectual disability and autism spectrum disorders 'on the fly': insights fromDisease models & mechanisms · 2019Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Memory formation has been shown recently to be dependent on energy status in Drosophila. A well-established energy sensor is the insulin signaling (InS) pathway. Previous studies in various animal models including human have revealed the role of insulin levels in short-term memory but its role in long-term memory remains less clear. We therefore investigated genetically the spatial and temporal role of InS using the olfactory learning and long-term memory model in Drosophila. We found that InS is involved in both learning and memory. InS in the mushroom body is required for learning and long-term memory whereas long-term memory specifically is impaired after InS signaling disruption in the ellipsoid body, where it regulates the level of p70s6k, a downstream target of InS and a marker of protein synthesis. Finally, we show also that InS is acutely required for long-term memory formation in adult flies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.