Evidence map›Paper›PMID 25805936›Full record

ArticleWorld journal of gastroenterology2015

Hepcidin/ferroportin expression levels involve efficacy of pegylated-interferon plus ribavirin in hepatitis C virus-infected liver.

Motoyuki Kohjima, Tsuyoshi Yoshimoto, Munechika Enjoji, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Yusuke Sasaki, Yasushi Shimonaka and 9 more

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Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Motoyuki KohjimaMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Tsuyoshi YoshimotoMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Munechika EnjojiMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Nobuyoshi FukushimaMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Kunitaka FukuizumiMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Tsukasa NakamuraMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Miho KurokawaMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Nao FujimoriMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Yusuke SasakiMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Yasushi ShimonakaMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Yusuke MurataMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Susumu KoyamaMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Ken KawabeMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Kazuhiro HaraguchiMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Yorinobu SumidaMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Naohiko HaradaMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Masaki KatoMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Kazuhiro KotohMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Makoto NakamutaMotoyuki Kohjima, Tsuyoshi Yoshimoto, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Makoto Nakamuta, Department of Gastroenterology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan.
Fukuoka University · JPNational Kyushu Medical Center · JPKyushu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the relationship between the iron-metabolism-related gene expression profiles and efficacy of antiviral therapy in chronic hepatitis C patients.

methodsThe hepatic expression profile of iron-metabolism-related genes was analyzed and its association with virological response to pegylated-interferon plus ribavirin combination therapy was evaluated. A hundred patients with chronic hepatitis C (genotype1b, n = 50; genotype 2, n = 50) were enrolled and retrospectively analyzed. Liver biopsy samples were subjected to quantitative polymerase chain reaction for iron-metabolism-related genes and protein expression (Western blotting analysis) for ferroportin. As a control, normal liver tissue was obtained from 18 living donors of liver transplantation. Serum hepcidin level was measured by sensitive liquid chromatography/electrospray ionization tandem mass spectrometry.

resultsIron overload is associated with liver damage by increasing oxidative stress and hepatitis C virus (HCV) is reported to induce iron accumulation in hepatocytes in vivo. Conversely, iron administration suppresses HCV replication in vitro. Therefore, the association between HCV infection and iron metabolism remains unclear. Compared with controls, patients had significantly higher gene expression for transferrin, iron-regulatory proteins 1 and 2, divalent metal transporter 1, and ferroportin, but similar for transferrin receptors 1 and 2, and hepcidin. When the expression profiles were compared between sustained virological response (SVR) and non-SVR patients, the former showed significantly lower transcription and protein expression of hepcidin and ferroportin. Expression of hepcidin-regulating genes, BMPR1, BMPR2, and hemojuvelin, was significantly increased, whereas BMP2 was decreased in HCV-infected liver. BMPR2 and hemojuvelin expression was significantly lower in the SVR than non-SVR group. HCV infection affects the expression of iron-metabolism-related genes, leading to iron accumulation in hepatocytes.

conclusionDecreased expression of hepcidin and ferroportin in SVR patients indicates the importance of hepatocytic iron retention for viral response during pegylated-interferon plus ribavirin treatment.

Indexed as

Antiviral AgentsBlotting, WesternCation Transport ProteinsChromatography, LiquidDrug Therapy, CombinationFemaleFerroportinGene Expression ProfilingGene Expression RegulationHepatitis C, ChronicHepcidinsHumansInterferon-alphaInterferon alpha-2LiverMaleAntiviral AgentsCation Transport ProteinsFerroportinHAMP protein, humanHepcidinsInterferon-alphaInterferon alpha-2peginterferon alfa-2apeginterferon alfa-2bPolyethylene GlycolsRecombinant ProteinsRibavirinChronic hepatitis CFerroportinHepcidinInterferonIron-metabolism

Identifiers

PMID25805936
PMCPMC4363759
OpenAlexW2098003911

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.